(E)-2'-benzyl-2(R)-[1(S)-(hydroxycarbamoyl)-4-phenyl-3-butenyl]-2'-(methanesulphonyl)-4-methylvalerohydrazide | 219612-58-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-2'-benzyl-2(R)-[1(S)-(hydroxycarbamoyl)-4-phenyl-3-butenyl]-2'-(methanesulphonyl)-4-methylvalerohydrazide
• 英文别名: (2S,3R)-3-[[benzyl(methylsulfonyl)amino]carbamoyl]-N-hydroxy-5-methyl-2-[(E)-3-phenylprop-2-enyl]hexanamide
• CAS: 219612-58-5
• 化学式: C₂₅H₃₃N₃O₅S
• 分子量: 487.62
• InChiKey: ZKHXUFQLUNYGCL-UKRIWCLYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  34
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  124
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] PHARMACOLOGICAL CHAPERONES FOR THE TREATMENT OF ALZHEIMER'S DISEASE<br/>[FR] CHAPERONS PHARMACOLOGIQUES POUR LE TRAITEMENT DE LA MALADIE D’ALZHEIMER
  申请人：AMICUS THERAPEUTICS INC

  公开号：WO2011011181A1

  公开（公告）日：2011-01-27

  The invention relates to methods of enhancing normal α-secretase expression, and to enhancing expression of an α-secretase having a mutation which affects protein folding and/or processing of the α-secretase. The invention provides a method of treating an individual having a condition in which increased expression or activity of an α-secretase in the central nervous system would be beneficial, by administering an effective amount of a pharmacologic chaperone for the α-secretase. The invention provides α-secretase inhibitors which have been identified as specific pharmacologic chaperones which enhance expression or enzymatic activity of α-secretase in the central nervous system.