2-mercaptooxazolo[4,5-g]phthalide | 213685-83-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-mercaptooxazolo[4,5-g]phthalide
• 英文别名: 2-Sulfanylidene-3,6-dihydrofuro[3,4-g][1,3]benzoxazol-8-one
• CAS: 213685-83-7
• 化学式: C₉H₅NO₃S
• 分子量: 207.21
• InChiKey: BEKTUCXQQUEACP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  79.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• NOVEL ANILIDE COMPOUNDS AND DRUGS CONTAINING THE SAME
  申请人：Kowa Co., Ltd.

  公开号：EP1020451A1

  公开（公告）日：2000-07-19

  The invention relates to a novel anilide compound and a pharmaceutical composition comprising the same. The invention relates to a compound represented by the following general formula:    represents a divalent residue of benzene with a substituent(s), heterocycle-condensed benzene which may or may not have a substituent, pyridine which may or may not have a substituent, cyclohexane or naphthalene or Ar represents an aryl group which may or may not have a substituent; X represents -NH-, oxygen atom or sulfur atom; Y represents -NR4-, oxygen atom, sulfur atom, sulfoxide or sulfone; Z represents single bond or -NR5-; R4 represents hydrogen atom, a lower alkyl group, an aryl group or a silylated lower alkyl group which may or may not have a substituent; R5 represents hydrogen atom, a lower alkyl group, an aryl group or a silylated lower alkyl group which may or may not have a substituent; and n represents an integer of 0 to 15. The inventive compounds are useful in the form of pharmaceutical composition, specifically as acyl coenzyme A cholesterol acyltransferase (ACAT) inhibitor.

  本发明涉及一种新型苯胺化合物和含有该化合物的药物组合物。本发明涉及由以下通式代表的化合物： 代表带有取代基的苯、可能带有也可能不带取代基的杂环缩合苯、可能带有也可能不带取代基的吡啶、环己烷或萘的二价残基 或 Ar 代表芳基，可以有取代基，也可以没有取代基； X 代表-NH-、氧原子或硫原子； Y 代表-NR4-、氧原子、硫原子、亚砜或砜； Z 代表单键或-NR5-； R4 代表氢原子、低级烷基、芳基或硅烷化低级烷基，可带有或不带有取代基； R5 代表氢原子、低级烷基、芳基或硅烷化低级烷基，可以有或没有取代基；以及 n 代表 0 至 15 的整数。 本发明化合物以药物组合物的形式使用，特别是作为酰基辅酶 A 胆固醇酰基转移酶（ACAT）抑制剂。
• Novel anilide compounds and drugs containing the same
  申请人：Kowa Company, Ltd.,Japan

  公开号：US20020099074A1

  公开（公告）日：2002-07-25

  The invention relates to a novel anilide compound and a pharmaceutical composition comprising the same. The invention relates to a compound represented by the following general formula: 1 represents a divalent residue of benzene with a substituent(s), heterocycle-condensed benzene which may or may not have a substituent, pyridine which may or may not have a substituent, cyclohexane or naphthalene 2 Ar represents an aryl group which may or may not have a substituent, X represents —NH—, oxygen atom or sulfur atom; Y represents —NR 4 —, oxygen atom, sulfur atom, sulfoxide or sulfone; Z represents single bond or —NR 5 —; R 4 represents hydrogen atom, a lower alkyl group, an aryl group or a silylated lower alkyl group which may or may not have a substituent; R 5 represents hydrogen atom, a lower alkyl group, an aryl group or a silylated lower alkyl group which may or may not have a substituent; and n represents an integer of 0 to 15. The inventive compounds are useful in the form of pharmaceutical composition, specifically as acyl coenzyme A cholesterol acyltransferase (ACAT) inhibitor.

  本发明涉及一种新型苯胺化合物和含有该化合物的药物组合物。本发明涉及一种由以下通式表示的化合物： 1 代表带有取代基的苯、可以带有或不带有取代基的杂环缩合苯、可以带有或不带有取代基的吡啶、环己烷或萘的二价残基 2 Ar 代表芳基，可以有取代基，也可以没有取代基、 X 代表-NH-、氧原子或硫原子； Y 代表-NR 4 -、氧原子、硫原子、亚砜或砜； Z 代表单键或-NR 5 -; R 4 代表氢原子、低级烷基、芳基或硅烷化低级烷基，可带有或不带有取代基； R 5 代表氢原子、低级烷基、芳基或硅烷化低级烷基，可带有或不带有取代基；以及 n 代表 0 至 15 的整数。 本发明化合物以药物组合物的形式使用，特别是作为酰基辅酶 A 胆固醇酰基转移酶（ACAT）抑制剂。
• ANILIDE COMPOUNDS AND DRUGS CONTAINING THE SAME
  申请人：Kowa Co., Ltd.

  公开号：EP1020451B1

  公开（公告）日：2005-06-15
• US6362208B1
  申请人：——

  公开号：US6362208B1

  公开（公告）日：2002-03-26
• US6797717B2
  申请人：——

  公开号：US6797717B2

  公开（公告）日：2004-09-28