3-tert-butyloxycarbonylamino-6-methyl-2-pyridinone | 369384-01-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-tert-butyloxycarbonylamino-6-methyl-2-pyridinone
• 英文别名: tert-butyl N-(2-hydroxy-6-methylpyridin-3-yl)carbamate；tert-butyl N-(6-methyl-2-oxo-1H-pyridin-3-yl)carbamate
• CAS: 369384-01-0
• 化学式: C₁₁H₁₆N₂O₃
• 分子量: 224.26
• InChiKey: FMJVOJMXGIXMTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• US6506754B1
  申请人：——

  公开号：US6506754B1

  公开（公告）日：2003-01-14
• [EN] NOVEL NON-COVALENT THROMBIN INHIBITORS<br/>[FR] NOUVEAUX INHIBITEURS DE THROMBINE DE TYPE NON COVALENT
  申请人：CORVAS INT INC

  公开号：WO2001079195A2

  公开（公告）日：2001-10-25

  The present invention provides compounds which have a pyrazinone or pyridinone ring at P3 and which feature at P1 a cyclic amino or amidino derivative. These compounds have biological activity as active and potent inhibitors of thrombin. Their pharmaceutically acceptable salts, pharmaceutical compositions thereof and methods of using these compounds and pharmaceutical compositions comprising these compounds as therapeutic agents for treatment of disease states in mammals which are characterized by abnormal thrombosis are also described.
• [EN] PYRIDINE AND PYRAZINE DERIVATIVES AS THROMBIN INHIBITORS<br/>[FR] NOUVEAUX INHIBITEURS DE THROMBINE DE TYPE NON COVALENT
  申请人：——

  公开号：WO2001079195A9

  公开（公告）日：2003-10-23

  [EN] The present invention provides compounds which have a pyrazinone or pyridinone ring at P3 and which feature at P1 a cyclic amino or amidino derivative. These compounds have biological activity as active and potent inhibitors of thrombin. Their pharmaceutically acceptable salts, pharmaceutical compositions thereof and methods of using these compounds and pharmaceutical compositions comprising these compounds as therapeutic agents for treatment of disease states in mammals which are characterized by abnormal thrombosis are also described.
  [FR] La présente invention concerne des composés comprenant un cycle de pyrazinone ou de pyridinone en position P3 et se caractérisant par la présence d'un dérivé amino ou amidino cyclique en position P1. Ces composés présentent une puissante activité biologique en tant qu'inhibiteurs de la thrombine. L'invention concerne également leurs sels pharmaceutiquement acceptables, leurs compositions pharmaceutiques et des méthodes d'utilisation desdits composés, ainsi que des compositions pharmaceutiques renfermant ces composés en tant qu'agents thérapeutiques destinés au traitement d'états pathologiques chez des mammifères présentant une thrombose anormale.
• [EN] PYRAZINONE AND PYRIDINONE DERIVATIVES AS THROMBIN INHIBITORS<br/>[FR] INHIBITEURS DE LA THROMBINE A BASE DE DERIVES DE PYRAZINONE ET PYRIDINONE
  申请人：CORVAS INT INC

  公开号：WO2001079262A1

  公开（公告）日：2001-10-25

  The present invention provides compounds which have a pyrazinone or pyridinone ring at P3 and which feature a six member heterocyclic ring having two ring nitrogen atoms and the remainder of the ring atoms carbon atoms at P1. These compounds have biological activity as active and potent inhibitors of thrombin. Their pharmaceutically acceptable salts, pharmaceutical compositions thereof and methods of using these compounds and pharmaceutical compositions comprising these compounds as therapeutic agents for treatment of disease states in mammals which are characterized by abnormal thrombosis are also described.