heronamide F | 1569311-23-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: heronamide F
• 英文别名: (3E,5E,7E,9S,10R,11Z,13E,15E,17E,20R)-20-[(2E,4E)-hexa-2,4-dienyl]-9,10-dihydroxy-7,15-dimethyl-1-azacycloicosa-3,5,7,11,13,15,17-heptaen-2-one
• CAS: 1569311-23-4
• 化学式: C₂₇H₃₅NO₃
• 分子量: 421.58
• InChiKey: FFBLFSFSCNGUGS-YGXGVOTQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  31
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  heronamide F 、 乙酸酐 在 吡啶 作用下， 以70 mg的产率得到heronamide F diacetate
  参考文献：
  名称：

  Heronamides D–F, Polyketide Macrolactams from the Deep-Sea-Derived Streptomyces sp. SCSIO 03032

  摘要：

  Three new macrolactams, heronamides D-F (1-3), were isolated from the deep-sea-derived Streptomyces sp. SCSIO 03032 upon changing cultivation conditions. The planar structures of heronamides D-F (1-3) were elucidated by extensive MS and NMR spectroscopic analyses and comparisons with the closely related heronamides A-C. The relative configurations of 1-3 were deduced by detailed analysis of (3)J(HH) values and NOESY data. The absolute configurations of 1 and 2 were determined by chemical modifications and application of the modified Mosher's method. None of the compounds exhibited obvious antimicrobial or cytotoxic activities.

  DOI：

  10.1021/np400665a