p-Toluolsulfonsaeuremethylester-d | 92401-89-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-Toluolsulfonsaeuremethylester-d
• 英文别名: toluene-4-sulfonic acid deuteriomethyl ester；Deuteriomethyl 4-methylbenzenesulfonate
• CAS: 92401-89-3
• 化学式: C₈H₁₀O₃S
• 分子量: 187.224
• InChiKey: VUQUOGPMUUJORT-VMNATFBRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• ONE CLASS OF PYRAZOLONE COMPOUNDS AND USE THEREOF
  申请人：Shanghai Institute Of Materia Medica Chinese Academy of Sciences

  公开号：EP3170823A1

  公开（公告）日：2017-05-24

  Provided in the present invention are one class of pyrazolone compounds and a use thereof. In particular, provided in the present invention is a compound as represented by general formula I, wherein the definition of each group is as described in the description. The compounds of the present invention have a direct AMPK-activating activity and can significantly promote the phosphorylation of AMPK and ACC of L6 myocytes and HepG2 cells in a dose-dependent manner.

  本发明提供了一类吡唑酮化合物及其用途。特别地，本发明提供了通式 I 所代表的化合物，其中各基团的定义如说明书所述。本发明的化合物具有直接激活 AMPK 的活性，能以剂量依赖的方式显著促进 L6 肌细胞和 HepG2 细胞的 AMPK 和 ACC 的磷酸化。
• One class of pyrazolone compounds and use thereof
  申请人：SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

  公开号：US10196389B2

  公开（公告）日：2019-02-05

  Provided are a class of pyrazolone compounds and a use thereof. In particular, a compound represented by formula I is provided, wherein the definition of each variable group is as described in the description. The compounds of formula (I) have a direct AMPK-activating activity and can significantly promote the phosphorylation of AMPK and ACC of L6 myocytes and HepG2 cells in a dose-dependent manner.

  本发明提供了一类吡唑酮化合物及其用途。特别是提供了一种由式 I 代表的化合物，其中各变量基团的定义如说明书所述。式（I）化合物具有直接激活 AMPK 的活性，能以剂量依赖的方式显著促进 L6 肌细胞和 HepG2 细胞的 AMPK 和 ACC 的磷酸化。
• 6,7-DIHYDRO-2H-PYRAZOLO[4,3-C]PYRIDIN-3(5H)-ONE DERIVATIVES AND THEIR USE FOR TREATING A DISEASE ASSOCIATED WITH AMPK KINASE ACTIVITY
  申请人：Shanghai Institute Of Materia Medica Chinese Academy of Sciences

  公开号：EP3170823B1

  公开（公告）日：2021-04-28