4-[(2,5-dimethyl-3-nitrophenyl)(hydroxy)methyl]-N,N-dimethyl-1H-imidazole-1-sulfonamide | 355133-82-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[(2,5-dimethyl-3-nitrophenyl)(hydroxy)methyl]-N,N-dimethyl-1H-imidazole-1-sulfonamide
• 英文别名: 4-[(2,5-dimethyl-3-nitrophenyl)-hydroxymethyl]-N,N-dimethylimidazole-1-sulfonamide
• CAS: 355133-82-3
• 化学式: C₁₄H₁₈N₄O₅S
• 分子量: 354.387
• InChiKey: SSCTYODFLJWNTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  130
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2,5-二甲基-3-硝基苯甲醛 、 N,N-二甲基-4-碘-1H-咪唑-1-磺酰胺 以to provide 260 mg (26%) of the title compound的产率得到4-[(2,5-dimethyl-3-nitrophenyl)(hydroxy)methyl]-N,N-dimethyl-1H-imidazole-1-sulfonamide
  参考文献：
  名称：

  4-Imidazole derivatives of benzyl and restricted benzyl sulfonamides, sulfamides, ureas, carbamates, and amides and their use

  摘要：

  公式I1的化合物在治疗由或减轻α1A激动剂预防的疾病方面非常有用。此外，还披露了α1A激动剂组合物和在哺乳动物体内激活α1肾上腺素能受体的方法。

  公开号：

  US20030073850A1

文献信息

• 4-IMIDAZOLE DERIVATIVES OF BENZYL AND RESTRICTED BENZYL SULFONAMIDES, SULFAMIDES, UREAS, CARBAMATES AND AMIDES AND THEIR USE AS ALPHA-1A AGONISTS
  申请人：Abbott Laboratories

  公开号：EP1259491A1

  公开（公告）日：2002-11-27
• [EN] 4-IMIDAZOLE DERIVATIVES OF BENZYL AND RESTRICTED BENZYL SULFONAMIDES, SULFAMIDES, UREAS, CARBAMATES, AND AMIDES AND THEIR USE AS ALPHA-1A AGONISTS<br/>[FR] DERIVES 4-IMIDAZOLE DE BENZYLE ET SULFONAMIDES DE BENZYLE, SULFAMIDES, UREES, CARBAMATES ET AMIDES RESTREINTS ET UTILISATION DE CES DERNIERS COMME AGONISTES ALPHA-1A
  申请人：ABBOTT LAB

  公开号：WO2001060802A1

  公开（公告）日：2001-08-23

  Compounds of formula (I) are useful in treating diseases prevented by or ameliorated with α1A agonists. Also disclosed are α1A agonist compositions and a method of activating α1 adrenoceptors in a mammal.