| 1590360-46-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• CAS: 1590360-46-5
• 化学式: C₁₂H₁₅N₅
• 分子量: 229.285
• InChiKey: WAKLMXKLAFNKAE-UHFFFAOYSA-N

物化性质

• 沸点：
  419.6±55.0 °C(predicted)
• 密度：
  1.17±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  在 四丁基溴化铵 、 caesium carbonate 、 copper(I) bromide 作用下， 以 1,4-二氧六环 为溶剂， 反应 10.0h， 以84%的产率得到3-(sec-butyl)-7-methyl-3H-imidazo[2,1-i]purine
  参考文献：
  名称：

  Copper-Catalyzed Intramolecular Cyclization ofN-Propargyl-Adenine: Synthesis of Purine-Fused Tricyclics

  摘要：

  A novel protocol to construct fluorescent purine-fused tricyclic products via intramolecular cyclization of N-propargyl-adenine has been developed. With CuBr as the catalyst, a series of purine-fused tricyclic products were obtained in good to excellent yields (19 examples, 75-89% yields). When R-2 was a hydrogen atom in N-propargyl-adenines, the reactions only afforded the endocyclic double bond products. When R-2 was an aryl group, the electron-onating groups favored the endocyclic double bond products, while the electron-withdrawing groups favored the exocyclic double bond products.

  DOI：

  10.1021/jo5001687
• 作为产物：
  描述：

  炔丙胺 、 9-sec-Butyl-6-chloro-9H-purine 在 三乙胺 作用下， 以 乙醇 为溶剂， 反应 6.0h， 生成
  参考文献：
  名称：

  Copper-Catalyzed Intramolecular Cyclization ofN-Propargyl-Adenine: Synthesis of Purine-Fused Tricyclics

  摘要：

  A novel protocol to construct fluorescent purine-fused tricyclic products via intramolecular cyclization of N-propargyl-adenine has been developed. With CuBr as the catalyst, a series of purine-fused tricyclic products were obtained in good to excellent yields (19 examples, 75-89% yields). When R-2 was a hydrogen atom in N-propargyl-adenines, the reactions only afforded the endocyclic double bond products. When R-2 was an aryl group, the electron-onating groups favored the endocyclic double bond products, while the electron-withdrawing groups favored the exocyclic double bond products.

  DOI：

  10.1021/jo5001687