Methyl 3-benzoyloxy-4-oxo-9-phenylmethoxypyrido[1,2-a]pyrimidine-2-carboxylate | 1087580-71-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: Methyl 3-benzoyloxy-4-oxo-9-phenylmethoxypyrido[1,2-a]pyrimidine-2-carboxylate
• 英文别名: methyl 3-benzoyloxy-4-oxo-9-phenylmethoxypyrido[1,2-a]pyrimidine-2-carboxylate
• CAS: 1087580-71-9
• 化学式: C₂₄H₁₈N₂O₆
• 分子量: 430.417
• InChiKey: NRJSTASTVSUGAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  94.5
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  methyl 9-(benzyloxy)-3-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylate 、 苯甲酰氯 在 吡啶 作用下， 生成 Methyl 3-benzoyloxy-4-oxo-9-phenylmethoxypyrido[1,2-a]pyrimidine-2-carboxylate
  参考文献：
  名称：

  3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates—fast access to a heterocyclic scaffold for HIV-1 integrase inhibitors

  摘要：

  An efficient and reliable synthesis of the heterocyclic scaffold methyl-3-hydroxy-4-oxo-4H-pyrido-[1,2-a]pyrimidine-2-carboxylate is described. The scope of the synthesis regarding the introduction of substituents on the pyrido-fused ring is explored. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.09.010

文献信息

• 3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates—fast access to a heterocyclic scaffold for HIV-1 integrase inhibitors
  作者：Olaf D. Kinzel、Richard G. Ball、Monica Donghi、Courtney K. Maguire、Ester Muraglia、Silvia Pesci、Michael Rowley、Vincenzo Summa

  DOI：10.1016/j.tetlet.2008.09.010

  日期：2008.11

  An efficient and reliable synthesis of the heterocyclic scaffold methyl-3-hydroxy-4-oxo-4H-pyrido-[1,2-a]pyrimidine-2-carboxylate is described. The scope of the synthesis regarding the introduction of substituents on the pyrido-fused ring is explored. (C) 2008 Elsevier Ltd. All rights reserved.