1-Butanol+pyridine | 13624-64-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-Butanol+pyridine
• 英文别名: n-butanol pyridine；butanol pyridine；n-Butanol.pyridine；butan-1-ol;pyridine
• CAS: 13624-64-1
• 化学式: C₄H₁₀O*C₅H₅N
• 分子量: 153.224
• InChiKey: SAQIIXUDKZKSPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.86
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Safe natural pharmaceutical composition for treating cancer
  申请人：——

  公开号：US20040072790A1

  公开（公告）日：2004-04-15

  The present invention related to the natural drug of Homoharringtonine (HHT) combined with other ingredients which include Matrine (MAT), Apigenin (APN), Yejuhua lactone (YLE), Lipopolysaccharide of Kelp (LIK), Puerarin (PUN) and Indirubin (IND) for diverting human cancer cells to closely normal cells, inducing apoptosis of cancer cells and inhibiting cancer cells. Specifically, this invention provides a new method for producing HHT and other ingredients

  本发明涉及与其他成分结合的自然药物霍米哈林汀（HHT），这些成分包括苦参碱（MAT）、芹菜素（APN）、野菊花内酯（YLE）、海带脂多糖（LIK）、葛根素（PUN）和靛蓝（IND），用于将人类癌细胞转变为接近正常细胞，诱导癌细胞凋亡并抑制癌细胞。具体而言，本发明提供了一种生产HHT和其他成分的新方法。
• Luminescent compounds
  申请人：Terpetschnig A. Ewald

  公开号：US20050202565A1

  公开（公告）日：2005-09-15

  The invention provides reporter compounds based on squaric, croconic, and/or rhodizonic acid, among others, reactive intermediates used to synthesize the reporter compounds, and methods of synthesizing and using the reporter compounds, among others. The reporter compounds relate generally to the following structure Here, Z is a four, five, or six-member aromatic ring, and A, B, C, D, E, and F are substituents of Z, where F is absent when Z is a five-member ring, and where E and F are absent when Z is a four-member ring. A, B, C, D, E, and F are selected from a variety of elements and groups, including but not necessarily limited to O, S, Se, Te, N—R a , C(R b )(R c ), W 1 , and W 2 .

  本发明提供基于苯二酐、丁二酮和/或罗地酸等反应中间体的报告化合物，用于合成报告化合物的反应中间体以及合成和使用报告化合物的方法等。报告化合物通常与以下结构相关： 在此，Z是四、五或六元芳环，A、B、C、D、E和F是Z的取代基，当Z为五元环时，F缺失，当Z为四元环时，E和F缺失。A、B、C、D、E和F从各种元素和基团中选择，包括但不限于O、S、Se、Te、N—Ra、C(Rb)(Rc)、W1和W2。
• PROPHYLACTIC AND THERAPEUTIC AGENT FOR INFLAMMATORY INTESTINAL DISEASES
  申请人：CCI CORPORATION

  公开号：EP0965344A1

  公开（公告）日：1999-12-22

  A prophylactic and therapeutic agent for inflammatory intestinal diseases comprising as the active ingredient a chromanol glucoside represented by general formula (1), wherein R1, R2, R3, and R4, which may be the same or different, represent each a hydrogen atom or a lower alkyl group; R5 represents a hydrogen atom, a lower alkyl group, or a lower acyl group; X represents a monosaccharide residue or an oligosaccharide residue wherein the hydrogen atom(s) of the hydroxyl group(s) in the saccharide residue may be substituted with a lower alkyl group or a lower acyl group; n is an integer of 0 to 6; and m is an integer of 1 to 6. Since it contains as the active ingredient the chromanol glucoside which is soluble in water and possesses excellent antioxidation activity and anti-free radical activity, it can significantly prevent any pathological change in inflammatory intestinal diseases and markedly improve the pathology. Further, it can be made into an aqueous preparation containing the active ingredient in a high concentration and the aqueous preparation can effectively act in a small amount on the affected part to prevent or treat inflammatory intestinal diseases and, since no side effect accompanies, can be very safely used.

  一种肠道炎症性疾病的预防和治疗剂，其活性成分包括通式(1)代表的色醇葡萄糖苷，其中R1、R2、R3和R4可以相同或不同，各自代表氢原子或低级烷基；R5 代表氢原子、低级烷基或低级酰基； X 代表单糖残基或寡糖残基，其中糖残基中羟基的氢原子可被低级烷基或低级酰基取代； n 是 0 到 6 的整数；m 是 1 到 6 的整数。由于它的有效成分是可溶于水的色原醇葡萄糖苷，具有极佳的抗氧化活性和抗自由基活性，因此可以显著预防肠道炎症性疾病的病理变化，明显改善病理状况。此外，它还可以制成含有高浓度活性成分的水制剂，该水制剂只需少量就能有效地作用于患病部位，预防或治疗肠道炎症性疾病，而且由于没有副作用，使用非常安全。
• VITAMIN E DERIVATIVES
  申请人：Senju Pharmaceutical Co., Ltd.

  公开号：EP1043322A1

  公开（公告）日：2000-10-11

  Novel vitamin E derivatives represented by general formula (I) or pharmacologically acceptable salts thereof which are useful as hepatopathy inhibitors, anticataract agents, cerebral metabolism activators, antioxidants and cosmetic components. In Formula (I), R1 and R2 are the same or different and each represents hydrogen or methyl; R3 represents an SH compound bonded via an S-bond selected from among glutathione, γ-glutamylcysteine, cysteine, penicillamine, esters thereof and cysteamine, and R4 represents hydroxy, an N-substituted amino acid selected from among glycine, β-alanine, γ-aminobutyric acid, 5-aminovaleric acid, ε-aminocaproic acid, anthranilic acid, tranexamic acid, proline, esters thereof, aminoethylsulfonic acid and aminoethylsulfinic acid, or serotonin.

  由通式(I)代表的新型维生素 E 衍生物或其药理上可接受的盐，可用作肝病抑制剂、抗白内障剂、脑代谢激活剂、抗氧化剂和化妆品成分。在式（I）中，R1 和 R2 相同或不同，各自代表氢或甲基；R3 代表通过 S 键结合的 SH 化合物，选自谷胱甘肽、γ-谷氨酰半胱氨酸、半胱氨酸、青霉胺、其酯类和半胱胺；以及 R4 代表羟基、N-取代氨基酸，选自甘氨酸、β-谷氨酰半胱氨酸、γ-谷氨酰半胱氨酸、半胱氨酸、青霉胺、其酯类和半胱胺、β-丙氨酸、γ-氨基丁酸、5-氨基戊酸、ε-氨基己酸、蚁酸、氨甲环酸、脯氨酸、其酯类、氨乙基磺酸和氨乙基亚磺酸或羟色胺。
• PREVENTIVES AND REMEDIES FOR ISCHEMIC REFLOW DISORDER
  申请人：CCI CORPORATION

  公开号：EP1066832A1

  公开（公告）日：2001-01-10

  An agent for preventing and curing the hindrance of ischemic reperfusiton is disclosed which has as an active component thereof a chromanol glycoside represented by the following general formula: [wherein R1, R2, R3, and R4 independently denote a hydrogen atom or a lower alkyl group, R5 denotes a hydrogen atom, a lower alkyl group, or a lower acyl group, X denotes a monosaccharide residue or an oligosaccharide residue which may have a lower alkyl group or a lower acyl group substituted for the hydrogen atom of the hydroxyl group of the saccharide residue, n denotes an integer of 0 - 6, and m denotes an integer of 1 - 6]. The agent, even in a small dosage, acts safely and effectively on the affected part and allows the hindrances of ischemic reperfusion induced in heart, stomach, small intestine, liver, spleen, kidney, brain, and skin, and the hindrance induced during the transplantation of an internal organ to be prevented and cured.

  本发明公开了一种用于预防和治疗缺血再灌注障碍的制剂，其活性成分为由下式通式表示的色醇苷： [其中，R1、R2、R3 和 R4 分别表示氢原子或低级烷基，R5 表示氢原子、低级烷基或低级酰基，X 表示单糖残基或低聚糖残基，其中糖残基羟基的氢原子可被低级烷基或低级酰基取代，n 表示 0-6 的整数，m 表示 1-6 的整数]。该制剂即使用量很少，也能安全有效地作用于受影响的部位，使心脏、胃、小肠、肝、脾、肾、脑和皮肤的缺血再灌注障碍以及内脏器官移植过程中的障碍得到预防和治愈。