4-[1,3-bis-(tert-butyldimethylsilanyloxy)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]pent-2-enoic acid methyl ester | 897386-78-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 4-[1,3-bis-(tert-butyldimethylsilanyloxy)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]pent-2-enoic acid methyl ester
• CAS: 897386-78-6
• 化学式: C₃₇H₆₂O₄Si₂
• 分子量: 627.068
• InChiKey: ABKUKTZXWFWWPE-ZSJJKNIUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.16
• 重原子数：
  43.0
• 可旋转键数：
  7.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  44.76
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  4-[1,3-bis-(tert-butyldimethylsilanyloxy)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]pent-2-enoic acid methyl ester 在 nickel dichloride sodium tetrahydroborate 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 2.0h， 以100%的产率得到4-[1,3-bis-(tert-butyldimethylsilanyloxy)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15-decahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid methyl ester
  参考文献：
  名称：

  Design and evaluation of new antipsoriatic antedrug candidates having 16-en-22-oxa-vitamin D3 structures

  摘要：

  Design, synthesis, and in vitro and in vivo evaluation of a series of antipsoriatic antedrugs having 16-en-22-oxa-vitamin D-3 are described. Among the seven compounds examined, two are promising: ester 5c and amide 5f, both of which exhibit greater potent antiproliferation activity with lessened calcemic activity than the presently prescribed maxacalcitol (2). (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.03.014
• 作为产物：
  描述：

  1α,3β-bis(tert-butyldimethylsilyloxy) pregna-5,7,17(Z)-triene 、 丙炔酸甲酯 在 氯化二乙基铝 作用下， 以 正己烷 、 二氯甲烷 为溶剂， 反应 3.0h， 以23%的产率得到4-[1,3-bis-(tert-butyldimethylsilanyloxy)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]pent-2-enoic acid methyl ester
  参考文献：
  名称：

  Design and evaluation of new antipsoriatic antedrug candidates having 16-en-22-oxa-vitamin D3 structures

  摘要：

  Design, synthesis, and in vitro and in vivo evaluation of a series of antipsoriatic antedrugs having 16-en-22-oxa-vitamin D-3 are described. Among the seven compounds examined, two are promising: ester 5c and amide 5f, both of which exhibit greater potent antiproliferation activity with lessened calcemic activity than the presently prescribed maxacalcitol (2). (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.03.014