9-Butyl-7-Ethoxycarbonyl-1,2,7,8-tetrahydro-9H-purine-2,8-dione | 172495-72-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 9-Butyl-7-Ethoxycarbonyl-1,2,7,8-tetrahydro-9H-purine-2,8-dione
• 英文别名: ethyl 9-butyl-2,8-dioxo-3H-purine-7-carboxylate
• CAS: 172495-72-6
• 化学式: C₁₂H₁₆N₄O₄
• 分子量: 280.283
• InChiKey: BYWGQYCJTDSTDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  91.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Novel purine derivatives and pharmaceutically acceptable salts thereof
  申请人：NIPPON ZOKI PHARMACEUTICAL CO., LTD.

  公开号：EP0673938A2

  公开（公告）日：1995-09-27

  An object of the present invention is to offer novel purine derivatives which exhibit an inhibitory action to nasal mucus secretion and are useful as pharmaceuticals, etc. and pharmaceutically acceptable salts thereof. The purine derivatives of the present invention are novel compounds which are represented by the following general formula (I). [In the formula, R is alkyl or cycloalkyl, or optionally-substituted phenyl or phenylalkyl; R' is hydrogen or -COOX; and X is alkyl, alkenyl, alkoxyalkyl, phenyl or phenylalkyl] The compounds of the present invention are useful as therapeutic and preventive agents to various types of rhinitis accompanied by acceleration of nasal mucus secretion and by sneezing reflex such as allergic rhinitis. Moreover, the compounds of the present invention are able to be administered orally and exhibit low toxicity, little side effect and high safety. Accordingly, a continuous administration for long term is possible and they have a very high utility as the drugs.

  本发明的目的是提供新型嘌呤衍生物，这些衍生物对鼻粘膜分泌有抑制作用，并可用作药物等及其药学上可接受的盐类。 本发明的嘌呤衍生物是由以下通式（I）表示的新型化合物。 [式中，R 是烷基或环烷基，或任选取代的苯基或苯基烷基；R'是氢或-COOX；X 是烷基、烯基、烷氧基烷基、苯基或苯基烷基。］ 本发明的化合物可作为治疗和预防各种鼻炎的药物，这些鼻炎伴有鼻涕分泌加速和打喷嚏反射，如过敏性鼻炎。此外，本发明的化合物可以口服给药，且毒性低、副作用小、安全性高。因此，可以长期连续给药，具有很高的药物效用。
• Purine derivatives and pharmaceutically acceptable salts thereof
  申请人：NIPPON ZOKI PHARMACEUTICAL CO., LTD.

  公开号：EP0673938B1

  公开（公告）日：1999-07-07
• US5658918A
  申请人：——

  公开号：US5658918A

  公开（公告）日：1997-08-19