(1S,2S)-trans-bis(diphenylphosphino)cyclohexane | 152884-78-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1S,2S)-trans-bis(diphenylphosphino)cyclohexane
• 英文别名: [(1S,2S)-2-diphenylphosphanylcyclohexyl]-diphenylphosphane
• CAS: 152884-78-1
• 化学式: C₃₀H₃₀P₂
• 分子量: 452.516
• InChiKey: YLDJNDYRGPTCKV-KYJUHHDHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• METHOD FOR SYNTHESIZING OPTICALLY ACTIVE CARBONYL COMPOUNDS
  申请人：BASF SE

  公开号：US20180057437A1

  公开（公告）日：2018-03-01

  The present invention relates to a process for the preparation of an optically active carbonyl compound by asymmetric hydrogenation of a prochiral α,β-unsaturated carbonyl compound with hydrogen in the presence of at least one optically active transition metal catalyst that is soluble in the reaction mixture and which has rhodium as catalytically active transition metal and a chiral, bidentate bisphosphine ligand, wherein the reaction mixture during the hydrogenation of the prochiral α,β-unsaturated carbonyl compound additionally comprises at least one compound of the general formula (I): in which R 1 , R 2 : are identical or different and are C 6 - to C 10 -aryl which is unsubstituted or carries one or more, e.g. 1, 2, 3, 4 or 5, substituents which are selected from C 1 - to C 6 -alkyl, C 3 - to C 6 -cycloalkyl, C 6 - to C 10 -aryl, C 1 - to C 6 -alkoxy and amino; Z is a group CHR 3 R 4 or aryl which is unsubstituted or carries one or more, e.g. 1, 2, 3, 4 or 5, substituents which are selected from C 1 - to C 6 -alkyl, C 3 - to C 6 -cycloalkyl, C 6 - to C 10 -aryl, C 1 - to C 6 -alkoxy and amino, wherein R 3 and R 4 are as defined in the claims and the description.

  本发明涉及一种通过在至少一种可溶于反应混合物中的光学活性过渡金属催化剂的存在下，将可溶性光学活性过渡金属铑和手性双膦配体作为催化活性过渡金属的α，β-不对称氢化的可半手性α，β-不饱和羰基化合物与氢气反应制备光学活性羰基化合物的方法。在氢化可半手性α，β-不饱和羰基化合物的过程中，反应混合物中还包括至少一种符合一般式（I）的化合物：其中 R1、R2：相同或不同，为未取代或带有一个或多个（例如1、2、3、4或5个）C6到C10芳基取代基的化合物，所述取代基选自C1到C6烷基、C3到C6环烷基、C6到C10芳基、C1到C6烷氧基和氨基；Z是一种基团CHR3R4或未取代或带有一个或多个（例如1、2、3、4或5个）取代基的芳基，所述取代基选自C1到C6烷基、C3到C6环烷基、C6到C10芳基、C1到C6烷氧基和氨基，其中R3和R4如权利要求和说明书中定义。
• Highly Active and Selective Ethylene Oligomerization Catalyst and Method of Preparing Hexene or Octene Using the Same
  申请人：Han Tack-Kyu

  公开号：US20120130086A1

  公开（公告）日：2012-05-24

  This invention relates to a chromium complex compound for selective ethylene oligomerization including a chiral ligand, and to a method of selectively preparing 1-hexene or 1-octene from ethylene using the same.

  这项发明涉及一种包括手性配体的铬配合物化合物，用于选择性乙烯寡聚化，以及使用该配合物从乙烯中选择性制备1-己烯或1-辛烯的方法。
• Chiral diphosphines via 2,3 -sigmatropic rearrangement.Application in asymmetric transition metal catalysis
  申请人：PPG-Sipsy S.C.A.

  公开号：EP1182205A1

  公开（公告）日：2002-02-27

  The present invention refers to Chiral diphosphines selected from a) diphosphines corresponding to the formula wherein R1 - R4 are each independently selected from substituted and unsubstituted hydrocarbyl groups, b) diphosphines corresponding to the formula wherein R1 - R4 are each independently selected from substituted and unsubstituted hydrocarbyl groups with the proviso that if R1 and R2 is phenyl at least one of R3 and R4 is different from phenyl c) diphosphines corresponding to the formula wherein R1 - R4 are each independently selected from substituted and unsubstituted hydrocarbyl groups and R5 and R6 are each independently selected from the group consisting of hydrogen, alkyl and residues of protecting groups, whereby R6 and R5 taking together may be an divalent substituent thereby forming a bicyclus, to a method of making same, to a method for preparing a chiral precursor suitable for making the new chiral diphosphines, to transition metal complexes comprising the chiral diphosphines of the present invention, and to the use of either the chiral diphosphines or their transition metal complexes in asymmetric synthesis.

  本发明涉及手性二膦化合物，所选的二膦化合物包括： a）符合以下式子的二膦化合物，其中R1-R4各自独立地选自取代和未取代的碳氢化合物基团； b）符合以下式子的二膦化合物，其中R1-R4各自独立地选自取代和未取代的碳氢化合物基团，但如果R1和R2是苯基，则R3和R4中至少有一个不同于苯基； c）符合以下式子的二膦化合物，其中R1-R4各自独立地选自取代和未取代的碳氢化合物基团，而R5和R6各自独立地选自氢、烷基和保护基残基的群，其中R6和R5可以一起取代成为一个双价取代基团，从而形成一个双环。本发明还涉及制备该手性二膦化合物的方法、制备适用于制备新手性二膦化合物的手性前体的方法、包括本发明的手性二膦化合物的过渡金属配合物，以及在不对称合成中使用手性二膦化合物或其过渡金属配合物的用途。
• Verfahren zur diastereoselektiven Hydrierung von Folsäure zu Tetrahydrofolsäure
  申请人：BASF Aktiengesellschaft

  公开号：EP0551642A1

  公开（公告）日：1993-07-21

  Verfahren zur diastereoselektiven Hydrierung von Folsäure zu Tetrahydrofolsäure, das dadurch gekennzeichnet ist, daß man die Hydrierung der Folsäure in Gegenwart eines immobilisierten Rhodium(I)-Komplexes eines optisch aktiven Diphosphins in einer neutralen wäßrigen Pufferlösung bei einem H₂-Druck von mehr als 20 bar und einer Temperatur von mehr als 60°C durchführt.

  叶酸非对映选择性氢化成四氢叶酸的工艺，其特征在于叶酸的氢化是在中性缓冲水溶液中，光学活性二膦的固定化铑（I）络合物存在下进行的，氢压大于 20 巴，温度大于 60°C。
• HIGHLY ACTIVE AND HIGHLY SELECTIVE ETHYLENE OLIGOMERIZATION CATALYST, AND PREPARATION METHOD OF HEXENE OR OCTENE USING SAME
  申请人：SK Innovation Co., Ltd.

  公开号：EP2543682A1

  公开（公告）日：2013-01-09

  This invention relates to a chromium complex compound for selective ethylene oligomerization including a chiral ligand, and to a method of selectively preparing 1-hexene or 1-octene from ethylene using the same.

  本发明涉及一种用于选择性乙烯低聚物化的铬络合物，包括一种手性配体，还涉及一种用其从乙烯中选择性制备 1-己烯或 1-辛烯的方法。