7-[3-(4-acetylpiperazin-1-yl)propoxy]-6-methoxy-4-{[4-(2-methoxyphenoxy)phenyl]amino}quinoline-3-carbonitrile | 433979-96-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 7-[3-(4-acetylpiperazin-1-yl)propoxy]-6-methoxy-4-{[4-(2-methoxyphenoxy)phenyl]amino}quinoline-3-carbonitrile
• 英文别名: 7-[3-(4-Acetylpiperazin-1-yl)propoxy]-6-methoxy-4-[4-(2-methoxyphenoxy)anilino]quinoline-3-carbonitrile
• CAS: 433979-96-5
• 化学式: C₃₃H₃₅N₅O₅
• 分子量: 581.671
• InChiKey: ITNCKHKPWGKFPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  43
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  109
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• Substituted quinolines as antitumor agents
  申请人：——

  公开号：US20040029898A1

  公开（公告）日：2004-02-12

  The invention provides a compound of Formula (Ia), or a pharmaceutically acceptable salt. prodrug or solvate thereof. The invention also provides a process for the preparation of a compound of Formula (Ia), pharmaceutical compositions of a compound of Formula (Ia) and methods for the treatment or prevention of cancer comprising administering an effective amount of a compound of Formula (Ia).

  该发明提供了化合物Ia的结构，或者其药用可接受的盐、前药或溶剂化合物。该发明还提供了一种制备化合物Ia的方法，化合物Ia的药用组合物以及治疗或预防癌症的方法，包括给予有效量的化合物Ia。
• SUBSTITUTED QUINOLINES AS ANTITUMOR AGENTS
  申请人：AstraZeneca AB

  公开号：EP1337524A1

  公开（公告）日：2003-08-27
• US7067532B2
  申请人：——

  公开号：US7067532B2

  公开（公告）日：2006-06-27
• US7402583B2
  申请人：——

  公开号：US7402583B2

  公开（公告）日：2008-07-22
• [EN] SUBSTITUTED QUINOLINES AS ANTITUMOR AGENTS<br/>[FR] QUINOLINES SUBSTITUEES COMME AGENTS ANTITUMORAUX
  申请人：ASTRAZENECA AB

  公开号：WO2002044166A1

  公开（公告）日：2002-06-06

  The invention provides a compound of Formula (Ia), or a pharmaceutically acceptable salt, pro-drug or solvate thereof. The invention also provides a process for the preparation of a compound of Formula (Ia), pharmaceutical compositions of a compound of Formula (Ia) and methods for the treatment or prevention of cancer comprising administering an effective amount of a compound of Formula (1a).