1-(4-fluorophenyl)-6-bromo-1,3-hexanedione | 304678-97-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-fluorophenyl)-6-bromo-1,3-hexanedione
• CAS: 304678-97-5
• 化学式: C₁₂H₁₂BrFO₂
• 分子量: 287.128
• InChiKey: UAMLHKQZPRHRFB-FLIBITNWSA-N

物化性质

• 沸点：
  385.3±42.0 °C(Predicted)
• 密度：
  1.470±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.63
• 重原子数：
  16.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  37.3
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  1-(4-fluorophenyl)-6-bromo-1,3-hexanedione 在 氨 作用下， 以 甲醇 为溶剂， 生成 (Z)-3-amino-1-(4-fluorophenyl)-6-hydroxyhex-2-en-1-one
  参考文献：
  名称：

  Syntheses and biological evaluation of 3-substituted amino-1-aryl-6-hydroxy-hex-2-ene-1-ones as antioxidant and hypolipidemic agents 1

  摘要：

  A new series of compounds belonging to 3-substituted amino-1-aryl-6-hydroxy-hex-2-ene-1-ones (4-12a-e) have been synthesized and evaluated for antioxidant and hypolipidemic activities. Amongst all the synthesized compounds, seven compounds, namely 5b, 5d, 6a, 8a, 8b, 10b and 11a, exhibit better antioxidant activity than probucol. Two compounds, 56 and 10b, have been evaluated in detail for antioxidant and hypolipidemic activities and show comparable activity profile to that of probucol and guggulipid. From the present study it may be postulated that the mechanism of action of these compounds could be through activation of lecithin cholesterol acyltransferase (LCAT), liver lipolytic activity, increased faecal bile acid secretion and inhibition of hepatic cholesterol biosynthesis. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(00)00159-0
• 作为产物：
  描述：

  1-(4-fluorophenyl)-6-hydroxy-1,3-hexanedione 在 三溴化磷 作用下， 以 二氯甲烷 为溶剂， 以65%的产率得到1-(4-fluorophenyl)-6-bromo-1,3-hexanedione
  参考文献：
  名称：

  Syntheses and biological evaluation of 3-substituted amino-1-aryl-6-hydroxy-hex-2-ene-1-ones as antioxidant and hypolipidemic agents 1

  摘要：

  A new series of compounds belonging to 3-substituted amino-1-aryl-6-hydroxy-hex-2-ene-1-ones (4-12a-e) have been synthesized and evaluated for antioxidant and hypolipidemic activities. Amongst all the synthesized compounds, seven compounds, namely 5b, 5d, 6a, 8a, 8b, 10b and 11a, exhibit better antioxidant activity than probucol. Two compounds, 56 and 10b, have been evaluated in detail for antioxidant and hypolipidemic activities and show comparable activity profile to that of probucol and guggulipid. From the present study it may be postulated that the mechanism of action of these compounds could be through activation of lecithin cholesterol acyltransferase (LCAT), liver lipolytic activity, increased faecal bile acid secretion and inhibition of hepatic cholesterol biosynthesis. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(00)00159-0

文献信息

• Syntheses and Biological Evaluation of Alkanediamines as Antioxidant and Hypolipidemic Agents
  作者：Sanjay Batra、Amiya P Bhaduri、Bhawani S Joshi、Raja Roy、Ashok K Khanna、Ramesh Chander

  DOI：10.1016/s0968-0896(01)00185-7

  日期：2001.12

  A new series of compounds belonging to N,N'- [bis (1-aryl-6-hydroxy-hex-2-ene-1-one-3-yl)-1,n-alkanediamines (2-5a-f) have been synthesized and evaluated for antioxidant and hypolipidemic activities. Amongst all the synthesized compounds, seven compounds namely 2c, 2e, 4c, 5b, 5c, 5e and 5f exhibit potent antioxidant activity. These compounds have also been evaluated for hypolipidemic activity.

  属于N，N'- [双（1-芳基-6-羟基-己二-2-烯-1-酮-3-基）-1，n-烷二胺（2-5a-f）的新化合物已经合成并评估了抗氧化和降血脂活性。在所有合成的化合物中，七个化合物即2c，2e，4c，5b，5c，5e和5f表现出有效的抗氧化活性。还已经评估了这些化合物的降血脂活性。