3-[(4,4-diphenyl-but-3-enylamino)-methyl]-phenol | 1093253-79-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[(4,4-diphenyl-but-3-enylamino)-methyl]-phenol
• 英文别名: 3-[(4,4-Diphenylbut-3-enylamino)methyl]phenol
• CAS: 1093253-79-2
• 化学式: C₂₃H₂₃NO
• 分子量: 329.442
• InChiKey: OXXMHBHCRXLDSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以186 mg的产率得到3-[(4,4-diphenyl-but-3-enylamino)-methyl]-phenol
  参考文献：
  名称：

  Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1–mGAT4

  摘要：

  A series of N-substituted aminomethylphenol derivatives was synthesized by reductive amination. To study the inhibitory potency of the target compounds at the murine GABA transporters (mGAT1-mGAT4), a [H-3]GABA uptake test system in a 96-well format based on HEK cells stably expressing mGAT1-mGAT4 was established and validated. Inhibitory potencies at mGAT1-mGAT4 in the micromolar range and a slight subtype selectivity for mGAT3 were observed for the synthesized aminomethylphenol derivatives. Among the compounds investigated 5-n-dodecylaminomethyl-2-methoxyphenol (21) was found to be most potent with an IC50 value at mGAT3 of about 3 mu M. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.01.005

文献信息

• [EN] DIPHENYL-AMINE DERIVATIVES: USES, PROCESS OF SYNTHESIS AND PHARMACEUTICAL COMPOSITIONS<br/>[FR] DÉRIVÉS DE DIPHÉNYLAMINE : UTILISATIONS, PROCÉDÉS DE SYNTHÈSE ET COMPOSITIONS PHARMACEUTIQUES
  申请人：FAES FARMA SA

  公开号：WO2012069442A1

  公开（公告）日：2012-05-31

  The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, prodrug or solvate thereof, a method of synthesis of said compounds, pharmaceutical compositions comprising them and their use as a medicament for treating inflammatory diseases.

  本发明涉及式(I)的化合物：或其药物可接受的盐、前药或溶剂化物，所述化合物的合成方法，包含它们的制药组合物以及它们作为治疗炎症性疾病的药物的用途。
• Diphenyl-amine derivatives: uses, process of synthesis and pharmaceutical compositions
  申请人：FAES FARMA, S.A.

  公开号：EP2465498A1

  公开（公告）日：2012-06-20

  The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, prodrug or solvate thereof, a method of synthesis of said compounds, pharmaceutical compositions comprising them and their use as a medicament for treating inflammatory diseases.

  该发明涉及以下化合物的公式(I)：或其药用可接受的盐、前药或溶剂化合物，以及合成该化合物的方法，包括它们的药物组合物和它们作为治疗炎症性疾病的药物的用途。
• DIPHENYL-AMINE DERIVATIVES: USES, PROCESS OF SYNTHESIS AND PHARMACEUTICAL COMPOSITIONS
  申请人：Rodes Solanes Rosa

  公开号：US20130296346A1

  公开（公告）日：2013-11-07

  The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, prodrug or solvate thereof, a method of synthesis of said compounds, pharmaceutical compositions comprising them and their use as a medicament for treating inflammatory diseases.

  本发明涉及以下式子(I)的化合物：或其药学上可接受的盐、前药或溶剂化物，以及制备该化合物的方法、包含它们的制药组合物以及将它们用作治疗炎症性疾病的药物的用途。