O-ethyl (2,2-diethyl-3-methyl-4-oxocyclobutyl)sulfanylmethanethioate | 1582271-84-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫代缩醛
• 英文名称: O-ethyl (2,2-diethyl-3-methyl-4-oxocyclobutyl)sulfanylmethanethioate
• CAS: 1582271-84-8
• 化学式: C₁₂H₂₀O₂S₂
• 分子量: 260.422
• InChiKey: SMWVDXBJWASCOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  83.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tert-butyl azete-1(2H)-carboxylate 、 O-ethyl (2,2-diethyl-3-methyl-4-oxocyclobutyl)sulfanylmethanethioate 在 2,6-二甲基吡啶 、 过氧化双月桂酰 作用下， 以 乙酸乙酯 为溶剂， 反应 0.25h， 生成 tert-butyl 3-(2,2-diethyl-3-methyl-4-oxocyclobutyl)-2-((ethoxycarbonothioyl)thio)azetidine-1-carboxylate
  参考文献：
  名称：

  Modular Approach to Substituted Boc-Protected 4-(Aminomethyl)pyrroles

  摘要：

  The radical addition of various alpha-xanthyl ketones to Boc-protected azetine gives adducts which, when treated with ammonia or primary amines, furnish 2,4-disubstituted, 2,3,4-trisubstituted, and polycyclic pyrroles having a protected aminomethyl group at position 4. An unusual ring-opening was observed in the case of a cyclobutanone precursor.

  DOI：

  10.1021/ol500544u

文献信息

• Modular Approach to Substituted Boc-Protected 4-(Aminomethyl)pyrroles
  作者：Songzhe Han、Samir Z. Zard

  DOI：10.1021/ol500544u

  日期：2014.4.4

  The radical addition of various alpha-xanthyl ketones to Boc-protected azetine gives adducts which, when treated with ammonia or primary amines, furnish 2,4-disubstituted, 2,3,4-trisubstituted, and polycyclic pyrroles having a protected aminomethyl group at position 4. An unusual ring-opening was observed in the case of a cyclobutanone precursor.