1-tert.-Butyl-4-methylurazol | 64739-62-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1-tert.-Butyl-4-methylurazol
• 英文别名: 1-tert-butyl-4-methyl-[1,2,4]triazolidine-3,5-dione；1-Tert-butyl-4-methyl-1,2,4-triazolidine-3,5-dione
• CAS: 64739-62-4
• 化学式: C₇H₁₃N₃O₂
• 分子量: 171.199
• InChiKey: DFQRRVJEJXFKOT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  52.6
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Metal catalyzed dearomative 1,2-carboamination
  申请人：The Board of Trustees of the University of Illinois

  公开号：US10336737B2

  公开（公告）日：2019-07-02

  Described herein is the development of an arenophile-mediated, nickel-catalyzed dearomative trans-1,2-carboamination protocol. A range of readily available aromatic compounds was converted to the corresponding dienes using Grignard reagents as nucleophiles. This strategy provided products with exclusive trans-selectivity and high enantioselectivity was observed in case of benzene and naphthalene. The utility of this methodology was showcased by controlled and stereoselective preparation of small, functionalized molecules. A concise synthesis of (+)-pancratistatin and (+)-7-deoxypancratistatin from benzene using an enantioselective, dearomative carboamination strategy has been achieved. This approach, in combination with the judicious choice of subsequent olefin-type difunctionalization reactions, permits rapid and controlled access to a hexasubstituted core. Finally, minimal use of intermediary steps as well as direct, late stage C-7 hydroxylation provides both natural products in six and seven operations.

  本文介绍了一种由亲腈剂介导、镍催化的脱芳香反式-1,2-羧化反应。以格氏试剂为亲核剂，一系列现成的芳香族化合物被转化为相应的二烯。这种方法提供的产品具有独特的反式选择性，苯和萘的对映选择性也很高。通过控制和立体选择性制备功能化小分子，展示了这一方法的实用性。 利用对映选择性脱芳羧化策略，以苯为原料简便地合成了 (+)-pancratistatin 和 (+)-7-deoxypancratistatin 。这种方法与后续烯烃类双官能化反应的明智选择相结合，可以快速、可控地获得六代核心。最后，使用最少的中间步骤以及直接的后期 C-7 羟基化反应，只需六次和七次操作就能得到两种天然产品。
• OXIDATION CATALYST
  申请人：Asahi Kasei Chemicals Corporation

  公开号：EP1655070B1

  公开（公告）日：2015-07-15
• Oxidation catalyst
  申请人：Suzuki Ken

  公开号：US20060229471A1

  公开（公告）日：2006-10-12

  An oxidation catalyst for use in the oxidation of a substrate with a molecular oxygen, comprising at least one member selected from the group consisting of a specific hydrazyl radical (such as 2,2-diphenyl-1-picrylhydrazyl) and a specific hydrazine compound (such as 2,2-diphenyl-1-picrylhydrazine). A method for producing a chemical compound, comprising contacting a substrate with a molecular oxygen in the presence of the above-mentioned oxidation catalyst.
• US8133834B2
  申请人：——

  公开号：US8133834B2

  公开（公告）日：2012-03-13