硫代苯甲酸钠 | 51066-54-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 硫代苯甲酸钠
• 中文别名: 4-{(E)-[(4-甲氧苯基)亚氨基]甲基}苯基戊基碳酸酯
• CAS: 51066-54-7
• 化学式: C7H6NaOS
• 分子量: 161.18
• InChiKey: NWEACUXKAHGUQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.38
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  18.1
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2930909090

文献信息

• 1-Methylcarbapenem derivatives
  申请人：SANKYO COMPANY, LIMITED

  公开号：US20040014962A1

  公开（公告）日：2004-01-22

  1-Methylcarbapenem compounds having antibacterial activity, pharmacologically acceptable esters or salts thereof and pharmaceutical compositions (particularly antibacterial agents) containing them as an active ingredient are described. In addition, the invention includes the use of these compounds, ester derivatives or salts for the manufacture of pharmaceutical compositions, or a method for the prevention or treatment of diseases (particularly bacterial infections) by administering a pharmacologically effective amount of the compounds, ester derivatives or salts to warm-blooded animals (particularly human beings).

  描述了具有抗菌活性的1-甲基碳青霉烯化合物、它们的药物可接受的酯或盐，以及含有它们作为活性成分的药物组合物（特别是抗菌剂）。此外，发明包括这些化合物、酯衍生物或盐用于制造药物组合物，或通过向温血动物（特别是人类）投给药物有效量的这些化合物、酯衍生物或盐，用于预防或治疗疾病（特别是细菌感染）的方法。
• 2'-deoxy-L-nucleosides
  申请人：Watanabe Kyoichi

  公开号：US20050090660A1

  公开（公告）日：2005-04-28

  This invention provides processes for the preparation of compounds having the structure: wherein X and Y are same or different, and H, OH, OR, SH, SR, NH 2 , NHR′, or NR′R″ Z is H, F, Cl, Br, I, CN, or NH 2 . R is hydrogen, halogen, lower alkyl of C 1 -C 6 or aralkyl, NO 2 , NH 2 , NHR′, NR′R″, OH, OR, SH, SR, CN, CONH 2 , CSNH 2 , CO 2 H, CO 2 R′, CH 2 CO 2 H, CH 2 CO 2 R′, CH═CHR, CH 2 CH═CHR, or C═CR. R′ and R″ are same or different, and lower alkyl of C 1 -C 6 . R 13 is hydrogen, alkyl, acyl, phosphate (monophosphate, diphosphate, triphosphate, or stabilized phosphate) or silyl; and

  这项发明提供了制备具有以下结构的化合物的方法： 其中 X和Y相同或不同，且H、OH、OR、SH、SR、NH2、NHR′或NR′R″ Z为H、F、Cl、Br、I、CN或NH2 R为氢、卤素、C1-C6的低碳烷基或芳基烷基、NO2、NH2、NHR′、NR′R″、OH、OR、SH、SR、CN、CONH2、CSNH2、CO2H、CO2R′、CH2CO2H、CH2CO2R′、CH═CHR、CH2CH═CHR或C═CR。 R′和R″相同或不同，且为C1-C6的低碳烷基。 R13为氢、烷基、酰基、磷酸酯（单磷酸酯、二磷酸酯、三磷酸酯或稳定磷酸酯）或硅基。
• Vitamin d derivatives
  申请人：——

  公开号：US20040019023A1

  公开（公告）日：2004-01-29

  The object of the present invention is to provide vitamin D derivatives that have excellent physiological activities as medicines, particularly as therapeutic agents for skin diseases such as psoriasis, and that have a reduced hypercalcemic effect. The present invention provides a vitamin D derivative of Formula (1): 1 wherein X represents an oxygen atom or a sulfur atom; m represents a number of 1 to 3; R 1 and R 2 each represent a hydrogen atom or an alkyl group; R 4 and R 5 each represent a hydrogen atom or a hydroxyl group, etc.; R 3 represents —YR 8 , etc.; R 6 represents a hydrogen atom, etc.; and R 7 represents a hydrogen atom, etc.

  本发明的目的是提供作为药物的维生素D衍生物，特别是作为治疗银屑病等皮肤疾病的治疗剂，并且具有减少高钙血症作用的维生素D衍生物。 本发明提供了化学式（1）的维生素D衍生物： 1 其中 X代表氧原子或硫原子； m代表1至3的数字； R 1 和R 2 分别代表氢原子或烷基； R 4 和R 5 分别代表氢原子或羟基等； R 3 代表—YR 8 等； R 6 代表氢原子等；以及 R 7 代表氢原子等。
• Processes for the preparation of carbapenem-type antibacterial agents
  申请人：SANKYO COMPANY, LIMITED

  公开号：US20030225055A1

  公开（公告）日：2003-12-04

  A process for the preparation of a carbapenem antibacterial compound of the following formula (4) having a 1-alkylpyrrolidine structure or a salt thereof, a useful synthetic intermediate of the following formula (1) or a salt thereof, and a process for the preparation thereof: 1 wherein R 1 represents a C 1 -C 3 alkyl group, R 2 and R 3 each independently represents a hydrogen atom or an organic residue or R 2 and R 3 together with the nitrogen atom they are attached to form a ring.

  一种制备以下式（4）具有1-烷基吡咯烷结构或其盐的卡巴比林类抗菌化合物的方法，以及以下式（1）或其盐的有用合成中间体，以及其制备方法：其中R1代表C1-C3烷基基团，R2和R3各自独立地代表氢原子或有机残基，或R2和R3与它们连接的氮原子一起形成环。
• New 8-substituted derivatives of an anhydrooctonic acid, methods for their preparation, pharmaceutical preparations containing these and intermediates
  申请人：Astra Läkemedel Aktiebolag

  公开号：EP0234178A1

  公开（公告）日：1987-09-02

  Novel compounds of the formula wherein Y is hydrogen, halogen, amino, acylamino, acyloxy, azido, mercapto, thiocarboxy, the groups in which AA is an amino acid or peptide and W is OH or the same as AA; or physiologically acceptable salts thereof, processes for their preparation, pharmaceutical preparations containing the compounds, use of the compounds, and methods for treatment, and chemical intermediates. The compounds are active as enzyme inhibitors and useful as antibacterial agents or as intermediates for preparing antibacterial agents.

  新化合物的公式，其中Y是氢、卤素、氨基、酰胺基、酰氧基、叠氮基、巯基、硫代羧基的基团，AA是氨基酸或肽，W是OH或与AA相同；或其生理上可接受的盐，其制备方法，含有这些化合物的药物制剂，这些化合物的用途，治疗方法和化学中间体。这些化合物作为酶抑制剂活性，并可用作抗菌剂或用于制备抗菌剂的中间体。