Pyridoxal-phosphat | 75625-22-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Pyridoxal-phosphat
• 英文别名: [4-Formyl-5-(hydroxymethyl)-2-methylpyridin-3-yl] dihydrogen phosphate
• CAS: 75625-22-8
• 化学式: C₈H₁₀NO₆P
• 分子量: 247.144
• InChiKey: BFPLUJJVPWVSQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  117
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
  申请人：Brazeau J. Brian

  公开号：US20060252135A1

  公开（公告）日：2006-11-09

  Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(indoly-3-ylmethyl)-4-keto glutaric acid, an intermediate that is formed in certain monatin synthesis pathways, including some biosynthetic pathways.

  Monatin和某些立体异构体，如R，R monatin和S，R monatin，以及它们的盐，是使用多肽和生物合成途径生产的。这些多肽和生物合成途径也可用于生产R-2-羟基-2-（吲哚-3-基甲基）-4-酮戊二酸，这是某些monatin合成途径中形成的中间体，包括一些生物合成途径。
• Aldolases, nucleic acids encoding them and methods for making and using them
  申请人：Burke Ellen

  公开号：US20080020435A1

  公开（公告）日：2008-01-24

  This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S,R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R,R and S,R configurations, and salts thereof.

  本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如，但不限于HMG和/或KHG醛缩酶活性，编码这些多肽的多核苷酸以及制备和使用这些多核苷酸和多肽的方法。在某些实施例中，本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如，但不限于HMG和/或KHG醛缩酶活性，包括热稳定和热耐受活性，以及编码这些酶的多核苷酸，并制备和使用这些多核苷酸和多肽。根据本发明的多肽可以在各种制药、农业和工业背景下使用。在某些实施例中，本发明提供了用于生产R-2-羟基2-(吲哚-3-甲基)-4-酮戊二酸（R-MP）和某些单味噌味酸的立体异构体（如R，R和S，R单味噌味酸及其盐）以及某些单味噌味酸衍生物的立体异构体（如R，R和S，R构型及其盐）的多肽和生物合成途径。
• Aldolases, Nucleic Acids Encoding Them and Methods for Making and Using Them
  申请人：Weiner David P.

  公开号：US20100095390A1

  公开（公告）日：2010-04-15

  This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S,R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R,R and S,R configurations, and salts thereof.

  本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如，但不限于，HMG和/或KHG醛缩酶活性，编码这些多肽的多核苷酸以及制备和使用这些多核苷酸和多肽的方法。在某些实施例中，本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如，但不限于，HMG和/或KHG醛缩酶活性，包括热稳定和耐热活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。根据本发明的多肽可以在各种制药、农业和工业环境中使用。在某些实施例中，本发明提供了用于生产R-2-羟基2-(吲哚-3-甲基)-4-酮戊二酸（R-MP）和某些单甜味物质的立体异构体，例如R，R和S，R单甜味物质及其盐，以及某些单甜味物质衍生物的立体异构体，例如R，R和S，R构型及其盐的多肽和生物合成途径。
• POLYPEPTIDES AND BIOSYNTHETIC PATHWAYS FOR THE PRODUCTION OF STEREOISOMERS OF MONATIN AND THEIR PERCURSORS
  申请人：BRAZEAU Brian J.

  公开号：US20120164697A1

  公开（公告）日：2012-06-28

  Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(indoly-3-ylmethyl)-4-keto glutaric acid, an intermediate that is formed in certain monatin synthesis pathways, including some biosynthetic pathways.

  Monatin和其某些立体异构体，如R，R monatin和S，R monatin，以及其盐，是使用多肽和生物合成途径生产的。这些多肽和生物合成途径也可用于生产R-2-羟基-2-（吲哚-3-基甲基）-4-酮戊二酸，这是某些Monatin合成途径（包括一些生物合成途径）中形成的中间体。
• ALDOLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM
  申请人：BURKE Ellen

  公开号：US20120009634A1

  公开（公告）日：2012-01-12

  This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S, R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R,R and S,R configurations, and salts thereof.

  本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，编码这些多肽的多核苷酸以及制备和使用这些多核苷酸和多肽的方法。在某些实施例中，本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，包括热稳定和耐热活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。根据本发明的多肽可以在各种制药、农业和工业背景下使用。在某些实施例中，本发明提供了用于生产R-2-羟基2-(吲哚-3-甲基)-4-酮戊二酸(R-MP)和某些单甘氨酸的立体异构体，例如R,R和S,R单甘氨酸及其盐，以及某些单甘氨酸衍生物的立体异构体，例如R,R和S,R构型及其盐的多肽和生物合成途径。