N-(1-benzyl-4-vinyl-4-piperidinyl)-2,2,2-trichloroacetamide | 785783-57-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(1-benzyl-4-vinyl-4-piperidinyl)-2,2,2-trichloroacetamide
• 英文别名: N-(1-benzyl-4-ethenylpiperidin-4-yl)-2,2,2-trichloroacetamide
• CAS: 785783-57-5
• 化学式: C₁₆H₁₉Cl₃N₂O
• 分子量: 361.699
• InChiKey: WQFHHLYAGNDQTH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(1-benzyl-4-vinyl-4-piperidinyl)-2,2,2-trichloroacetamide 在 甲醇 、 sodium hydroxide 、 水 作用下， 反应 5.0h， 生成 1-benzyl-4-vinyl-4-piperidinamide
  参考文献：
  名称：

  EP1619193

  摘要：

  公开号：

文献信息

• Spiro-piperidine compounds and medicinal use thereof
  申请人：Nishizawa Rena

  公开号：US20060229301A1

  公开（公告）日：2006-10-12

  The present invention relates to a spiro-piperidine compound represented by formula (I): wherein R 1 represents hydrogen, an aliphatic hydrocarbon group which may have a substituent(s) or a cyclic group which may have a substituent(s); and ring A represents a 5- to 8-membered cyclic group which may have a substituent(s), a salt thereof, an N-oxide thereof, a quaternary ammonium salt thereof or a solvate thereof, or a prodrug thereof. The compounds represented by formula (I) have chemokine antagonistic action, so that they are useful for prevention and/or treatment of various inflammatory diseases, immune diseases such as autoimmune diseases or allergic diseases, or HIV infection.

  本发明涉及一种由式（I）表示的螺环哌啶化合物：其中R1表示氢，可能具有取代基的脂肪烃基或可能具有取代基的环状基团；环A表示可能具有取代基的5-至8-成员环状基团，其盐，N-氧化物，季铵盐或溶剂化物，或其前药。式（I）所表示的化合物具有趋化因子拮抗作用，因此它们对于预防和/或治疗各种炎症性疾病，免疫性疾病如自身免疫性疾病或过敏性疾病，或HIV感染是有用的。
• SPIRO-PIPERIDINE COMPOUNDS AND MEDICINAL USE THEREOF
  申请人：Nishizawa Rena

  公开号：US20100261641A1

  公开（公告）日：2010-10-14

  The present invention relates to a spiro-piperidine compound represented by formula (I): wherein R 1 represents hydrogen, an aliphatic hydrocarbon group which may have a substituent(s) or a cyclic group which may have a substituent(s); and ring A represents a 5- to 8-membered cyclic group which may have a substituent(s), a salt thereof, an N-oxide thereof, a quaternary ammonium salt thereof or a solvate thereof, or a prodrug thereof. The compounds represented by formula (I) have chemokine antagonistic action, so that they are useful for prevention and/or treatment of various inflammatory diseases, immune diseases such as autoimmune diseases or allergic diseases, or HIV infection.

  本发明涉及一种由式(I)表示的螺环哌啶化合物：其中，R1表示氢、可能具有取代基的脂肪烃基或可能具有取代基的环状基团；环A表示可能具有取代基的5-至8-成员环状基团，其盐、N-氧化物、季铵盐或溶剂化物，或其前药。式(I)所表示的化合物具有趋化因子拮抗作用，因此它们在预防和/或治疗各种炎症性疾病、免疫性疾病，如自身免疫性疾病或过敏性疾病，或HIV感染方面非常有用。
• SPIROPIPERIDINE COMPOUND AND MEDICINAL USE THEREOF
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1619193A1

  公开（公告）日：2006-01-25

  The present invention relates to a spiro-piperidine compound represented by formula (I): wherein R1 represents hydrogen, an aliphatic hydrocarbon group which may have a substituent(s) or a cyclic group which may have a substituent(s); and ring A represents a 5- to 8-membered cyclic group which may have a substituent(s), a salt thereof, an N-oxide thereof, a quaternary ammonium salt thereof or a solvate thereof, or a prodrug thereof The compounds represented by formula (I) have chemokine antagonistic action, so that they are useful for prevention and/or treatment of various inflammatory diseases, immune diseases such as autoimmune diseases or allergic diseases, or HIV infection.

  本发明涉及一种由式（I）表示的螺哌啶化合物： 其中 R1 代表氢、可具有取代基的脂肪族烃基或可具有取代基的环状基团；式（I）代表的化合物具有趋化因子拮抗作用，因此可用于预防和/或治疗各种炎症性疾病、免疫性疾病（如自身免疫性疾病或过敏性疾病）或 HIV 感染。
• Spiro-piperidine compounds as chemokine receptor antagonists and medicinal use thereof
  申请人：ONO Pharmaceutical Co., Ltd.

  公开号：EP2364982A1

  公开（公告）日：2011-09-14

  The present invention relates to a spiro-piperidine compound represented by formula (I): wherein R1 represents hydrogen, an aliphatic hydrocarbon group which may have a substituent(s) or a cyclic group which may have a substituent(s); and ring A represents a 5- to 8-membered cyclic group which may have a substituent(s), a salt thereof, an N-oxide thereof, a quaternary ammonium salt thereof or a solvate thereof, or a prodrug thereof. The compounds represented by formula (I) have chemokine antagonistic action, so that they are useful for prevention and/or treatment of various inflammatory diseases, immune diseases such as autoimmune diseases or allergic diseases, or HIV infection.

  本发明涉及一种由式（I）表示的螺哌啶化合物： 其中 R1 代表氢、可具有取代基的脂族烃基或可具有取代基的环状基团；环 A 代表可具有取代基的 5 至 8 元环状基团、其盐、其 N-氧化物、其季铵盐或其溶液或其原药。式 (I) 所代表的化合物具有趋化因子拮抗作用，因此可用于预防和/或治疗各种炎症性疾病、免疫性疾病（如自身免疫性疾病或过敏性疾病）或 HIV 感染。
• US7498323B2
  申请人：——

  公开号：US7498323B2

  公开（公告）日：2009-03-03