N-phenyl-2-(4-(trifluoromethyl)benzoyl)hydrazine-1-carboxamide | 857028-64-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-phenyl-2-(4-(trifluoromethyl)benzoyl)hydrazine-1-carboxamide
• CAS: 857028-64-9
• 化学式: C₁₅H₁₂F₃N₃O₂
• 分子量: 323.274
• InChiKey: XILYRBRPYSBNCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.17
• 重原子数：
  23.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  70.23
• 氢给体数：
  3.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  N-phenyl-2-(4-(trifluoromethyl)benzoyl)hydrazine-1-carboxamide 、 对硝基苯磺酰氯 在 polymer-supported 1,3,2-diazaphosphorinane derivative 作用下， 以 乙腈 为溶剂， 反应 0.33h， 以77%的产率得到4-nitro-N-phenyl-N-[5-(4-trifluoromethyl-phenyl)-[1,3,4]oxadiazol-2-yl]benzenesulfonamide
  参考文献：
  名称：

  The rapid preparation of 2-aminosulfonamide-1,3,4-oxadiazoles using polymer-supported reagents and microwave heating

  摘要：

  Herein, we report on the preparation of a library of 5-substituted-2-amino-1,3,4-oxadiazoles and the corresponding thiadiazole analogues. Presented is a one-pot preparation of the 2-ammosulfonylated analogues through a three component coupling of an acylhydrazine, an isocyanate and sulfonyl chloride promoted by a polymer-supported phosphazine base under microwave dielectric heating. Also described is the optimization process and details pertaining to the elucidation of the reaction products. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.03.062
• 作为产物：
  描述：

  4-(三氟甲基)亚苯基肼 、 异氰酸苯酯 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 N-phenyl-2-(4-(trifluoromethyl)benzoyl)hydrazine-1-carboxamide
  参考文献：
  名称：

  The rapid preparation of 2-aminosulfonamide-1,3,4-oxadiazoles using polymer-supported reagents and microwave heating

  摘要：

  Herein, we report on the preparation of a library of 5-substituted-2-amino-1,3,4-oxadiazoles and the corresponding thiadiazole analogues. Presented is a one-pot preparation of the 2-ammosulfonylated analogues through a three component coupling of an acylhydrazine, an isocyanate and sulfonyl chloride promoted by a polymer-supported phosphazine base under microwave dielectric heating. Also described is the optimization process and details pertaining to the elucidation of the reaction products. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.03.062