3-(3-methyl-2,4-dioxo-1-propyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-4-propoxy-N-(2-pyridin-2-yl-ethyl)benzenesulfonamide | 378794-13-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(3-methyl-2,4-dioxo-1-propyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-4-propoxy-N-(2-pyridin-2-yl-ethyl)benzenesulfonamide
• 英文别名: 3-(3-methyl-2,4-dioxo-1-propyl-5H-pyrrolo[3,2-d]pyrimidin-6-yl)-4-propoxy-N-(2-pyridin-2-ylethyl)benzenesulfonamide
• CAS: 378794-13-9
• 化学式: C₂₆H₃₁N₅O₅S
• 分子量: 525.629
• InChiKey: TYTLAKMDWPHGHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  37
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  133
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• 6-phenylpyrrolopyrimidinedione derivatives
  申请人：——

  公开号：US20030232838A1

  公开（公告）日：2003-12-18

  The invention relates to new 6-phenylpyrrolopyrimidine derivatives of formula (I): 1 wherein: —X—C—Y— represents 2 or —X—C—Y— represents 3 and to their use as selective cyclic GMP specific phosphodiesterase (PDE 5)inhibitors, processes for producing them, intermediates used in their production, compositions containing them and their applicability in medical treatment of the human or animal body.

  该发明涉及公式（I）的新6-苯基吡咯吡嘧啶衍生物：其中：—X—C—Y—代表2或—X—C—Y—代表3，并且它们作为选择性环磷酸鸟苷特异性磷酸二酯酶（PDE 5）抑制剂的用途，生产它们的方法，生产中使用的中间体，包含它们的组合物以及它们在医疗治疗人体或动物体内的适用性。
• 6-PHENYLPYRROLOPYRIMIDINEDIONE DERIVATIVES
  申请人：Almirall Prodesfarma, S.A.

  公开号：EP1286997A1

  公开（公告）日：2003-03-05
• US6943253B2
  申请人：——

  公开号：US6943253B2

  公开（公告）日：2005-09-13
• [EN] 6-PHENYLPYRROLOPYRIMIDINEDIONE DERIVATIVES<br/>[FR] DERIVES DE 6-PHENYL-PYRROLO-PYRIMIDINE
  申请人：ALMIRALL PRODESFARMA SA

  公开号：WO2001094350A1

  公开（公告）日：2001-12-13

  The invention relates to new 6-phenylpyrrolopyrimidine derivatives of formula (I): wherein -X-C-Y- represents (A) or -X-C-Y- represents (B) and to their use as selective cyclic GMP specific phosphodiesterase (PDE 5)inhibitors, processes for producing them, intermediates used in their production, compositions containing them and their applicability in medical treatment of the human or animal body.