4-(2-羟基-5-甲氧基)苯基-4-苯基-1-(N-甲基-N-苯基)氨基-1-氧代丁烷 | 104688-66-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(2-羟基-5-甲氧基)苯基-4-苯基-1-(N-甲基-N-苯基)氨基-1-氧代丁烷
• 英文名称: 4-(2-hydroxy-5-methoxy)phenyl-4-phenyl-1-(N-methyl-N-phenyl)amino-1-oxobutane
• 英文别名: 4-(2-hydroxy-5-methoxyphenyl)-N-methyl-N,4-diphenylbutanamide
• CAS: 104688-66-6
• 化学式: C₂₄H₂₅NO₃
• 分子量: 375.467
• InChiKey: FBRXGGXSMUNTIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  γ-苯基-γ-丁内酯 在 三乙胺 作用下， 以 甲苯 为溶剂， 反应 5.0h， 生成 4-(2-羟基-5-甲氧基)苯基-4-苯基-1-(N-甲基-N-苯基)氨基-1-氧代丁烷
  参考文献：
  名称：

  The synthesis and antilipidperoxidation activity of 4,4-diarylbutylamines and 4,4-diarylbutanamides.

  摘要：

  研究人员合成了一系列 4，4-二叔丁胺和 4，4-二叔丁酰胺衍生物，并对它们的抗脂质过氧化（ALP）活性和急性毒性（LD50）进行了评估。结果发现，其中一些衍生物具有显著的 ALP 活性。

  DOI：

  10.1248/cpb.38.1570

文献信息

• Diaryl butyric acid derivative and pharmaceutical use thereof
  申请人：Suntory Limited

  公开号：US04766116A1

  公开（公告）日：1988-08-23

  A diaryl butyric acid derivative having the general formula: ##STR1## wherein R.sup.1 represents a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, or an acyl group having 2 to 4 carbon atoms; R.sup.2 represents an alkyl group having 1 to 3 carbon atoms; and X represents a variety of substituents. This diaryl butyric acid derivative or the pharmaceutically acceptable salt thereof can be prepared by reacting a benzoxepin derivative having the general formula: ##STR2## wherein R.sup.2 is the same as defined above with an amine or alcohol derivative having the general formula; X--H wherein X is the same as defined above in the presence of an acid catalyst at room temperature or at an elevated temperature and, optionally, further reading the reaction product with an alkylation agent having 1 to 3 carbon atoms or an acylation agent having 2 to 4 carbon atoms. This diaryl butyric acid derivative or the pharmaceutically acceptable salt thereof is effective for ameliorating or treating various symptoms based on cerebral organic disorders and pathergasia.

  一种具有一般式的二芳基丁酸衍生物：##STR1##其中，R.sup.1代表氢原子，具有1至3个碳原子的烷基或具有2至4个碳原子的酰基；R.sup.2代表具有1至3个碳原子的烷基；X代表各种取代基。该二芳基丁酸衍生物或其药学上可接受的盐可通过将具有以下一般式的苯并噁唑衍生物：##STR2##其中，R.sup.2与上述定义相同，与具有以下一般式的胺或醇衍生物反应而制备得到：X--H，其中X与上述定义相同，在室温或升高温度下，在酸催化剂的存在下反应，并在必要时进一步与具有1至3个碳原子的烷基化试剂或具有2至4个碳原子的酰化试剂反应。该二芳基丁酸衍生物或其药学上可接受的盐对于改善或治疗基于脑器质性疾病和病理性言语障碍的各种症状有效。
• A diaryl butyric acid derivative and the production process thereof
  申请人：SUNTORY LIMITED

  公开号：EP0187524A2

  公开（公告）日：1986-07-16

  A diaryl butyric acid derivative having the general formula: . wherein R' represents a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, or an acyl group having 2 to 4 carbon atoms; R2 represents an alkyl group having 1 to 3 carbon atoms; and X represents a pyrrolidinyl group, a morpholino group, a thiomorpholino group, an amino group, a group having the general formula: wherein A represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, a group having the general formula: wherein B represents a phenyl group, a benzyl group, a aralkyl group having 7 to 9 carbon atoms substituted with or at least one hydroxyl group, a group having the general formula; wherein n is an integer of 0 to 5, D represents a saturated crosslinked ring type hydrocarbon group, a piperidinyl group, a morpholino group, a thiomorpholino group, a pyridyl group, an indolyl group, a piperazinyl group, a pyrrolidinyl group, a carboxyl group, a phenyl group substituted with a hydroxyl, or aryloxy group, an N-[4-(2'-hydroxy-5'-methoxy)phenyl-4-phenyl- butyryl]piperazinyl group, or a piperazinyl group having an alkyl group with 1 to 3 carbon atoms substituted for the hydrogen atom on the nitrogen atom a group having the general formula: wherein m is 2 to 3, f is an integer of 0 to 4, E is a hydrogen atom, a phenyl group, a hydroxyl group, a pyrrolidine-carboxyl group, a 4-(4'-methoxyphenyl)-4-phenylbutylamide group, or a 4-(2'-hyrdroxy-5'-methoxy)phenyl--4-phenylbutyryl group, a group having the general formula: wherein p is an integer of 2 to 4, and F presents a dialkylamino group having 1 to 3 carbon atoms, or a group having the general formula: wherein G represents an aralkyl group having 8 to 9 carbon atoms substituted with at least two hydroxyl groups; or the pharmaceutically acceptable salt thereof. This diaryl butyric acid derivative or the pharmaceutically acceptable salt thereof can be prepared by reacting a benzoxepin derivative having the general formula: wherein R2 is the same as defined above with an amine or alcohol derivative having the general formula; wherein X is the same as defined above in the presence of an acid catalyst at room temperature or at an elevated temperature and, optionally, further reacting the reaction product with an alkylation agent having 1 to 3 carbon atoms or an acylation agent having 2 to 4 carbon atoms, optionally further followed by treated with a pharmaceutically acceptable acid. This diaryl butyric acid derivative or the pharmaceutically acceptable salt thereof is effective for ameliorating and curing (or treating) various symptoms based on cerebral organic disorders and pathergasia.

  一种具有通式的二芳基丁酸衍生物： 其中 R'代表氢原子、具有 1 至 3 个碳原子的烷基或具有 2 至 4 个碳原子的酰基； R2 代表具有 1 至 3 个碳原子的烷基；以及 X 代表吡咯烷基、吗啉基、硫代吗啉基、氨基、通式如下的基团： 其中 A 代表氢原子或具有 1 至 3 个碳原子的烷基、通式为 其中 B 代表苯基、苄基、被至少一个羟基取代的具有 7 至 9 个碳原子的芳烷基、通式为 其中 n 为 0 至 5 的整数、 D 代表饱和交联环型烃基、哌啶基、吗啉基、硫代吗啉基、吡啶基、吲哚基、哌嗪基、吡咯烷基、羧基、被羟基取代的苯基或芳基氧基取代的苯基、N-[4-(2'-羟基-5'-甲氧基)苯基-4-苯基丁酰基]哌嗪基、或具有 1 至 3 个碳原子的烷基取代氮原子上氢原子的通式如下的基团的哌嗪基： 其中 m 为 2 至 3，f 为 0 至 4 的整数，E 为氢原子、苯基、羟基、吡咯烷羧基、4-(4'-甲氧基苯基)-4-苯基丁酰胺基团或 4-(2'-羟基-5'-甲氧基)苯基-4-苯基丁酰基，通式如下的基团： 其中 p 为 2 至 4 的整数，且 F 表示具有 1 至 3 个碳原子的二烷基氨基，或通式如下的基团 其中 G 代表至少被两个羟基取代的具有 8 至 9 个碳原子的芳烷基；或其药学上可接受的盐。 这种二芳基丁酸衍生物或其药学上可接受的盐可以通过反应具有通式的苯并氧杂卓衍生物来制备： 其中 R2 与上式定义相同，与具有通式的胺或醇衍生物反应； 其中 X与上式定义相同，在酸催化剂存在下，在室温或高温下反应，可选择将反应产物进一步与具有1至3个碳原子的烷基化剂或具有2至4个碳原子的酰化剂反应，可选择进一步用药学上可接受的酸处理。 这种二芳基丁酸衍生物或其药学上可接受的盐可有效改善和治愈（或治疗）基于脑器质性疾病和病变的各种症状。
• MIYANO, SCIJI;TATSUOKA, TOSHIO;SUZUKI, KENJI;IMAO, KAYOKO;SATOH, FUMIO;IS+, CHEM. AND PHARM. BULL., 38,(1990) N, C. 1570-1574
  作者：MIYANO, SCIJI、TATSUOKA, TOSHIO、SUZUKI, KENJI、IMAO, KAYOKO、SATOH, FUMIO、IS+

  DOI：——

  日期：——
• US4766116A
  申请人：——

  公开号：US4766116A

  公开（公告）日：1988-08-23
• The synthesis and antilipidperoxidation activity of 4,4-diarylbutylamines and 4,4-diarylbutanamides.
  作者：Seiji MIYANO、Toshio TATSUOKA、Kenji SUZUKI、Kayoko IMAO、Fumio SATOH、Tkafumi ISHIHARA、Ichiro HIROTSU、Tetsuro KIHARA、Mizuho HATTA、Yoshiko HORIKAWA、Kunihiro SUMOTO

  DOI：10.1248/cpb.38.1570

  日期：——

  A series of 4, 4-diarylbutylamine and 4, 4-diarylbutanamide derivatives has been synthesized and evaluated for their antilipidperoxidation (ALP) activity and acute toxicity (LD50). Some of them were found to have significant ALP activity.

  研究人员合成了一系列 4，4-二叔丁胺和 4，4-二叔丁酰胺衍生物，并对它们的抗脂质过氧化（ALP）活性和急性毒性（LD50）进行了评估。结果发现，其中一些衍生物具有显著的 ALP 活性。