N-(3-carbamoylphenyl)-2-phenyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide | 1616385-76-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-carbamoylphenyl)-2-phenyl-1H-pyrrolo[2,3-b]pyridine-5-carboxamide
• CAS: 1616385-76-2
• 化学式: C₂₁H₁₆N₄O₂
• 分子量: 356.384
• InChiKey: DKKVVMJKWOKEGV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] CRYSTALLINE FORMS OF 4-(1-(1,1-DI(PYRIDIN-2-YL)ETHYL)-6-(3,5-DIMETHYLISOXAZOL-4-YL)-1H- PYRROLO[3,2-B]PYRIDIN-3-YL)BENZOIC ACID THAT INHIBITS BROMODOMAIN<br/>[FR] FORMES CRISTALLINES DE L'ACIDE 4-(1-(1,1-DI(PYRIDIN-2-YL)ÉTHYL)-6-(3,5-DIMÉTHYLISOXAZOL-4-YL)-1H- PYRROLO[3,2-B]PYRIDIN-3-YL)BENZOÏQUE INHIBITEUR DE BROMODOMAINE
  申请人：PLEXXIKON INC

  公开号：WO2018175311A1

  公开（公告）日：2018-09-27

  Forms of 4-(1-(1,1-di(pyridin-2-yl)ethyl)-6-(3,5-dimethylisoxazol-4-yl)-1H-pyrrolo[3,2-b]pyridin-3-yl)benzoic acid were prepared and characterized in the solid state: Compound I. Also provided are processes of manufacture and methods of using the forms of Compound I.

  已经在固态中制备并表征了4-(1-(1,1-二(吡啶-2-基)乙基)-6-(3,5-二甲基异恶唑-4-基)-1H-吡咯[3,2-b]吡啶-3-基)苯甲酸的形式：化合物I。还提供了制备过程和使用化合物I形式的方法。
• HETEROCYCLIC COMPOUNDS AND USES THEREOF
  申请人：Plexxikon Inc.

  公开号：US20170081326A1

  公开（公告）日：2017-03-23

  Provided herein are heterocyclic compounds of Formula (I), pharmaceutical compositions containing such a compound and their therapeutic uses, methods for their preparation, intermediate compounds, pharmaceutical compositions containing such a compound, and their therapeutic uses.

  本文提供的是公式（I）的杂环化合物，包括含有该化合物的药物组合物及其治疗用途，制备方法，中间体化合物，含有该化合物的药物组合物以及其治疗用途。
• FORMULATIONS OF A COMPOUND MODULATING KINASES
  申请人：Plexxikon Inc.

  公开号：US20190031654A1

  公开（公告）日：2019-01-31

  Provided are compositions comprising Compound I having the following structure: or a pharmaceutically acceptable salt thereof, and a solubilizing agent; methods of making the same; and methods of using the same.

  所提供的组合物包括具有以下结构的化合物I：或其药学上可接受的盐和溶解剂；制备这些组合物的方法；以及使用这些组合物的方法。
• COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
  申请人：Plexxikon Inc.

  公开号：US20140213554A1

  公开（公告）日：2014-07-31

  Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and/or mutant c-kit protein kinases.

  本文介绍了对c-kit蛋白激酶或带有任何突变的突变c-kit蛋白激酶活性的化合物，以及制备和使用这些化合物治疗与c-kit蛋白激酶和/或突变c-kit蛋白激酶的异常活性相关的疾病和病状的方法。
• [EN] SOLID FORMS OF A COMPOUND FOR MODULATING KINASES<br/>[FR] FORMES SOLIDES D'UN COMPOSÉ POUR LA MODULATION DE KINASES
  申请人：PLEXXIKON INC

  公开号：WO2019075243A1

  公开（公告）日：2019-04-18

  Forms of 4-(6-(3,5-dimethylisoxazol-4-yl)-1-[(1S)-1-(2-pyridyl)ethyl]pyrrolo[3,2-b]pyridin-3- yl)benzoic acid (Compound I) were prepared and characterized in the solid state: (I). Also provided are processes of manufacture and methods of using the forms of Compound I.

  制备并表征了4-(6-(3,5-二甲基异噁唑-4-基)-1-[(1S)-1-(2-吡啶基)乙基]吡咯并[3,2-b]吡啶-3-基)苯甲酸（化合物I）的固态形式：（I）。同时提供了制造过程和使用化合物I的形式的方法。