(2S,3R)-1-tert-butoxycarbonyl-2-(3-thienylmethyl)pyrrolidin-3-amine | 872722-30-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (2S,3R)-1-tert-butoxycarbonyl-2-(3-thienylmethyl)pyrrolidin-3-amine
• 英文别名: tert-butyl (2S,3R)-3-amino-2-(thiophen-3-ylmethyl)pyrrolidine-1-carboxylate
• CAS: 872722-30-0
• 化学式: C₁₄H₂₂N₂O₂S
• 分子量: 282.407
• InChiKey: QNWXHMBUJYNCMY-NEPJUHHUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  83.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Pyrrolidin-3-Yl Compounds Useful as Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease
  申请人：Coburn Craig A.

  公开号：US20080287523A1

  公开（公告）日：2008-11-20

  The present invention is directed to pyrrolidin-3-yl derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

  本发明涉及吡咯烷基衍生物化合物，它们是β-分泌酶酶的抑制剂，并且在治疗涉及β-分泌酶酶的疾病，如阿尔茨海默病方面有用。本发明还涉及包含这些化合物的制药组合物，以及在治疗涉及β-分泌酶酶的疾病中使用这些化合物和组合物。
• US7714021B2
  申请人：——

  公开号：US7714021B2

  公开（公告）日：2010-05-11