N,N,N',N'-tetrakis[3-[bis[3-(pyridin-4-ylmethylideneamino)propyl]amino]propyl]butane-1,4-diamine | 1192578-38-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N,N,N',N'-tetrakis[3-[bis[3-(pyridin-4-ylmethylideneamino)propyl]amino]propyl]butane-1,4-diamine
• CAS: 1192578-38-3
• 化学式: C₈₈H₁₂₀N₂₂
• 分子量: 1486.07
• InChiKey: GMYOGUWNTHWSEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  110
• 可旋转键数：
  61
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  221
• 氢给体数：
  0
• 氢受体数：
  22

反应信息

• 作为反应物：
  描述：

  [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 二氯甲烷 、 N,N,N',N'-tetrakis[3-[bis[3-(pyridin-4-ylmethylideneamino)propyl]amino]propyl]butane-1,4-diamine 以 二氯甲烷 为溶剂， 以98.4%的产率得到
  参考文献：
  名称：

  Anticancer activity of multinuclear arene ruthenium complexes coordinated to dendritic polypyridyl scaffolds

  摘要：

  The rational development of multinuclear arene ruthenium complexes (arene = p-cymene, hexamethylbenzene) from generation 1 (G(1)) and generation 2 (G(2)) of 4-iminopyridyl based poly( propyleneimine) dendrimer scaffolds of the type, DAB-(NH2)(n) (n = 4 or 8, DAB = diaminobutane) has been accomplished in order to exploit the 'enhanced permeability and retention' (EPR) effect that allows large molecules to selectively enter cancer cells. Four compounds were synthesised, i.e. [{(p-cymene)RuCl2}(4)G(1)] (1), [{(hexamethylbenzene)RuCl2}(4)G(1)] (2), [{(p-cymene)RuCl2}(8)G(2)] (3), and [{(hexamethylbenzene)RuCl2}(8)G(2)] ( 4), by first reacting DAB-( NH2) n with 4-pyridinecarboxaldehyde and subsequently metallating the iminopyridyl dendrimers with [(p-cymene)RuCl2](2) or [(hexamethylbenzene)RuCl2](2). The related mononuclear complexes [(p-cymene) RuCl2(L)] (5) and [(hexamethylbenzene)RuCl2(L)] (6) were obtained in a similar manner from N-(pyridin-4-ylmethylene)propan-1-amine (L). The molecular structure of 5 has been determined by X-ray diffraction analysis and the in vitro anticancer activities of the mono-, tetra- and octanuclear complexes 1-6 studied on the A2780 human ovarian carcinoma cell line showing a close correlation between the size of the compound and cytotoxicity. (C) 2009 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2009.06.028

文献信息

• Hydroformylation activity of multinuclear rhodium complexes coordinated to dendritic iminopyridyl and iminophosphine scaffolds
  作者：Nathan C. Antonels、John R. Moss、Gregory S. Smith

  DOI：10.1016/j.jorganchem.2010.10.048

  日期：2011.5

  synthesis of poly(propyleneimine)-iminopyridyl and iminophosphine rhodium(I) metallodendrimers, with rhodium coordinated to monodentate (N-donor) and chelating, heterobidentate (P,N) moieties respectively located on the periphery, has been accomplished in order to evaluate their potential as hydroformylation catalysts. Related mononuclear complexes were obtained in a similar manner to model the multinuclear

  聚（丙烯亚胺）-亚氨基吡啶基和亚氨基膦铑（I）金属树枝状大分子的合成，铑配位成单齿（N-供体）和螯合，异双齿（P，N为了评估它们作为加氢甲酰化催化剂的潜力，已经完成了分别位于外围的部分。以相似的方式获得了相关的单核复合物，以对多核复合物进行建模。与类似的单核铑配合物相比，发现多核铑（I）配合物是1-辛烯加氢甲酰化反应中的有效催化剂前体，可实现更高的转化率，更快的反应速率和稍微增强的催化活性。使用四核和八核铑络合物的加氢甲酰化反应通常显示出醛的化学选择性形成，以及少量的异构化产物。