2-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)quinazolin-4(3H)-one | 1446556-92-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)quinazolin-4(3H)-one
• 英文别名: 2-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-3H-quinazolin-4-one
• CAS: 1446556-92-8
• 化学式: C₁₁H₅F₃N₄O₂
• 分子量: 282.182
• InChiKey: WJAFHKZYQHWCTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  80.4
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  邻氨基苯甲酸 在 溶剂黄146 作用下， 反应 3.67h， 生成 2-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)quinazolin-4(3H)-one
  参考文献：
  名称：

  A new library of 4(3H)- and 4,4′(3H,3H′)-quinazolinones and 2-(5-alkyl-1,2,4-oxadiazol-3-yl)quinazolin-4(3H)-one obtained from diaminoglyoxime

  摘要：

  New and efficient approaches are developed for the synthesis of a series of 4(3H)- and 4,4'(3H,3H')-quinazolinone derivatives and 2-(5-alkyl-1,2,4-oxadiazol-3-yl)quinazolin-4(3H)-one in good yields, via the reactions of diaminoglyoxime and anthranilic acid derivatives or methyl 2-aminobenzoate and acetic anhydride in acetic acid as the solvent under reflux conditions. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.05.065

文献信息

• A new library of 4(3H)- and 4,4′(3H,3H′)-quinazolinones and 2-(5-alkyl-1,2,4-oxadiazol-3-yl)quinazolin-4(3H)-one obtained from diaminoglyoxime
  作者：Abolghasem Moghimi、Rahim Hosseinzadeh Khanmiri、Ismail Omrani、Ahmad Shaabani

  DOI：10.1016/j.tetlet.2013.05.065

  日期：2013.7

  New and efficient approaches are developed for the synthesis of a series of 4(3H)- and 4,4'(3H,3H')-quinazolinone derivatives and 2-(5-alkyl-1,2,4-oxadiazol-3-yl)quinazolin-4(3H)-one in good yields, via the reactions of diaminoglyoxime and anthranilic acid derivatives or methyl 2-aminobenzoate and acetic anhydride in acetic acid as the solvent under reflux conditions. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.