tert-butyl 4-(((4-((6-(4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamido)pyridin-3-yl)oxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate | 1361248-01-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: tert-butyl 4-(((4-((6-(4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamido)pyridin-3-yl)oxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate
• 英文别名: Tert-butyl 4-[[4-[6-[[4-ethoxy-1-(4-fluoro-2-methylphenyl)pyrazole-3-carbonyl]amino]pyridin-3-yl]oxy-6-methoxyquinolin-7-yl]oxymethyl]piperidine-1-carboxylate
• CAS: 1361248-01-2
• 化学式: C₃₉H₄₃FN₆O₇
• 分子量: 726.805
• InChiKey: BGXYDFIGKRAUTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  53
• 可旋转键数：
  13
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  139
• 氢给体数：
  1
• 氢受体数：
  11

文献信息

• PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS
  申请人：Schultz-Fademrecht Carsten

  公开号：US20140018365A1

  公开（公告）日：2014-01-16

  The present invention relates to 1-nitrogen-heterocyclic-2-carboxamides and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the treatment and/or prevention of Axl receptor tyrosine kinase subfamily induced disorders, including cancer and primary tumor metastases, and pharmaceutical compositions containing at least one of said 1-nitrogen-heterocyclic-2-carboxamide derivatives and/or pharmaceutically acceptable salts thereof.

  本发明涉及1-氮杂环-2-羧酰胺和/或其药学上可接受的盐，这些衍生物被用作药物活性剂，特别用于治疗和/或预防Axl受体酪氨酸激酶亚家族引起的疾病，包括癌症和原发性肿瘤转移，以及含有至少一种所述的1-氮杂环-2-羧酰胺衍生物和/或其药学上可接受的盐的制药组合物。
• US8999982B2
  申请人：——

  公开号：US8999982B2

  公开（公告）日：2015-04-07
• [EN] PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS<br/>[FR] COMPOSÉS PHARMACEUTIQUEMENT ACTIFS EN TANT QU'INHIBITEURS DE AXL
  申请人：LEAD DISCOVERY CENTER GMBH

  公开号：WO2012028332A1

  公开（公告）日：2012-03-08

  The present invention relates to 1-nitrogen-heterocyclic-2-carboxamides of general formula (I): and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the treatment and/or prevention of Axl receptor tyrosine kinase subfamily induced disorders, including cancer and primary tumor metastases, and pharmaceutical compositions containing at least one of said 1-nitrogen-heterocyclic-2-carboxamide derivatives and/or pharmaceutically acceptable salts thereof.