(S)-3-(5-(3-aminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine | 1585941-30-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-3-(5-(3-aminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine
• CAS: 1585941-30-5
• 化学式: C₂₂H₂₉FN₂O
• 分子量: 356.483
• InChiKey: NSSPAPDKNCPTJX-QFIPXVFZSA-N

物化性质

• 熔点：
  68-70 °C
• 沸点：
  459.0±45.0 °C(predicted)
• 密度：
  1.101±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  (S)-(3-(1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-yl)acrylonitrile) 在 sodium tetrahydroborate 、 cobalt(II) chloride 作用下， 以 甲醇 为溶剂， 以46%的产率得到(S)-3-(5-(3-aminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-1-yl)-N,N-dimethylpropan-1-amine
  参考文献：
  名称：

  Novel and High Affinity Fluorescent Ligands for the Serotonin Transporter Based on (S)-Citalopram

  摘要：

  Novel rhodamine-labeled ligands, based on (S)citalopram, were synthesized and evaluated for uptake inhibition at the human serotonin, dopamine, and norepinephrine transporters (hSERT, hDAT, and hNET, respectively) and for binding at SERT, in transiently transfected COS7 cells. Compound 14 demonstrated high affinity binding and selectivity for SERT (K-i; = 3 nM). Visualization of SERT, using confocal laser scanning microscopy, validated compound 14 as a novel tool for studying SERT expression and distribution in living cells.

  DOI：

  10.1021/ml5000806