2,2'-dimethyl-6,6'-bis(di-3,5-xylyl phosphino)-1,1'-biphenyl | 849240-31-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2'-dimethyl-6,6'-bis(di-3,5-xylyl phosphino)-1,1'-biphenyl
• 英文别名: [2-[2-Bis(3,5-dimethylphenyl)phosphanyl-6-methylphenyl]-3-methylphenyl]-bis(3,5-dimethylphenyl)phosphane
• CAS: 849240-31-9
• 化学式: C₄₆H₄₈P₂
• 分子量: 662.835
• InChiKey: FNHLWKCEIWYLOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.6
• 重原子数：
  48
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• COBALT PHOSPHINE ALKYL COMPLEXES FOR THE ASYMMETRIC HYDROGENATION OF ALKENES
  申请人：The Trustees of Princeton University

  公开号：US20130281747A1

  公开（公告）日：2013-10-24

  Disclosed herein are manganese, iron, nickel, or cobalt compounds having a bidentate ligand and the use of these compounds for the hydrogenation of alkenes, particularly the asymmetric hydrogenation of prochiral olefins.

  本文披露了具有双齿配体的锰、铁、镍或钴化合物，以及这些化合物在烯烃的加氢反应中的应用，特别是对前手性烯烃的不对称加氢。
• Process for the production of optically active amino alcohols
  申请人：Takasago International Corporation

  公开号：EP1398310A1

  公开（公告）日：2004-03-17

  The disclosure describes a process for the preparation of cyclic optically active amino alcohols of formula (I) by reacting an optically active hydroxycarboxylate of formula (IV) with hydrazine to form an optically active hydroxycarboxylic hydrazide compound of formula (III), then conducting a Curtius reaction in the presence of an alcohol to give an optically active alkoxycarbonylamino alcohol of formula (II), followed by deprotecting the amino group to form the amino alcohol of formula (I). The variables A1, A2, R1-R6, m, n and * are as defined in the claims.

  该披露描述了一种制备公式(I)的环状光学活性氨醇的过程，方法是将公式(IV)的光学活性羟基羧酸酯与肼反应，形成公式(III)的光学活性羟基羧酰肼化合物，然后在醇的存在下进行Curtius反应，得到公式(II)的光学活性烷氧羰基氨醇，然后去保护氨基以形成公式(I)的氨基醇。变量A1、A2、R1-R6、m、n和*的定义如索赔中所述。
• METHOD FOR PRODUCING OPTICALLY ACTIVE 2,3-DIHYDROFARNESAL
  申请人：TAKASAGO INTERNATIONAL CORPORATION

  公开号：US20150218072A1

  公开（公告）日：2015-08-06

  A method for producing an optically active 2,3-dihydrofarnesal of formula (1) is disclosed. The method includes subjecting β-farnesene f formula (2) to amination in the presence of a lithium salt of an amine to obtain (2E)-farnesyl allylamine of general formula (3); subjecting the (2E)-farnesyl allylamine to asymmetric isomerization to obtain an optically active farnesyl enamine of general formula (4); and subjecting the optically active farnesyl enamine to solvolysis:

  揭示了一种生产式（1）的光学活性2,3-二氢法尼醛的方法。该方法包括在胺的锂盐存在下，使β-法尼烯（式2）经胺化反应得到（2E）-法尼基丙烯胺（一般式3）；将（2E）-法尼基丙烯胺经不对称异构化反应得到光学活性法尼基亚胺（一般式4）；以及将光学活性法尼基亚胺经溶剂解离：
• Method for producing 1-menthol
  申请人：——

  公开号：US20020007094A1

  公开（公告）日：2002-01-17

  Provided is a method for the production of 1-menthol, which comprises hydrogenation of piperitenone with a transition metal complex of a specified optically active phosphine to produce pulegone, hydrogenation of the obtained pulegone with a ruthenium-phosphine-amine complex in the presence of base to obtain pulegol, and further hydrogenation of the pulegol with a transition metal catalyst.

  提供一种生产1-薄荷醇的方法，该方法包括使用指定的光学活性膦的过渡金属配合物对薄荷酮进行氢化反应，以生产薄荷醛，然后在碱的存在下使用钌膦胺配合物对所得的薄荷醛进行氢化反应，以获得薄荷醇，最后再使用过渡金属催化剂对薄荷醇进行进一步的氢化反应。
• Process for producing optically active gamma-butyrolactone
  申请人：——

  公开号：US20030105341A1

  公开（公告）日：2003-06-05

  This invention provides a novel process for producing optically active 3-hydroxy-&ggr;-butyrolactone in a short step, which is superior economically and in efficiency and industrially suitable by using a starting material which is inexpensive and easily available and reagents easy to handle. This invention relates to a process for producing optically active 3-hydroxy-&ggr;-butyrolactone represented by formula I: 1 wherein the symbol * means an asymmetric carbon atom, which comprises hydrogenating an optically active 4-substituted oxy-3-hydroxybutyrate represented by formula II: 2 wherein R 1 represents a C 1-4 lower alkyl group, R 2 represents a protective group for a hydroxyl group deprotected by hydrogenation with a heterogeneous hydrogenation catalyst, and the symbol * has the same meaning as defined above, in the presence of a heterogeneous hydrogenation catalyst and an acidic substance followed by deprotection and simultaneous ring closure thereof.

  本发明提供了一种新的生产光学活性3-羟基-γ-丁内酯的工艺，该工艺步骤短，经济高效，适合工业应用，使用的起始材料廉价易得，试剂易于处理。本发明涉及一种生产光学活性3-羟基-γ-丁内酯的工艺，其化学式为I:1，其中符号*表示不对称碳原子，包括在异质催化剂和酸性物质的存在下，氢化化合式II:2所代表的光学活性4-取代氧基-3-羟基丁酸酯，其中R1表示C1-4较低烷基基团，R2表示羟基的保护基，通过脱保护和同时环闭反应。