N,N'-Bis-p-tolylsulfonylbenzolsulfinamidin | 81221-66-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-Bis-p-tolylsulfonylbenzolsulfinamidin
• 英文别名: N,N'-bis-(toluene-4-sulfonyl)-benzenesulfinamidine；N,N'-Bis-(toluol-4-sulfonyl)-benzolsulfinamidin；4-methyl-N-[N-(4-methylphenyl)sulfonyl-S-phenylsulfinimidoyl]benzenesulfonamide
• CAS: 81221-66-1
• 化学式: C₂₀H₂₀N₂O₄S₃
• 分子量: 448.588
• InChiKey: FFGHNXYFGGXLNO-UHFFFAOYSA-N

物化性质

• 熔点：
  155-156 °C
• 沸点：
  643.2±58.0 °C(Predicted)
• 密度：
  1.36±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  129
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  异丙醇 以45%的产率得到
  参考文献：
  名称：

  FISCHER, E.;BULLCZAK, M., SULFUR LETT., 6,(1987) N 6, 191-196

  摘要：

  DOI：

文献信息

• Constructing <i>N</i>-Acyl/<i>N</i>-Sulfonyl Aza-Sulfur Derivatives from Amides/Sulfonamides and Thiophthalimides via Oxidant Regulation
  作者：Yazhou Li、Yongkun Wang、Feifei Fang、Yu Zhang、Chunpu Li、Tao Yu、Qiangqiang Chen、Jiang Wang、Hong Liu

  DOI：10.1021/acs.orglett.3c02166

  日期：2023.8.18

  Here, we have constructed five distinct types of N-acyl or N-sulfonyl aza-sulfur scaffolds using readily available (sulfon)amides and thiophthalimides with precise regulation of oxidants. Our novel methods feature one-pot mild reaction conditions and simple operation, thereby making them highly convenient for the late-stage diversification of various amide drugs, bioactive molecules, and peptides.

  在这里，我们使用现成的（磺）酰胺和硫代邻苯二甲酰亚胺以及精确调节氧化剂构建了五种不同类型的N-酰基或N-磺酰基氮杂硫支架。我们的新方法具有一锅法反应条件温和、操作简单的特点，非常方便各种酰胺类药物、生物活性分子和肽的后期多样化。
• Comparison of the reactivity ofN-(p-toluenesulfonyl)-sulfinimidoyl fluorides and chlorides toward triphenylphosphine
  作者：Valeriy E. Pashinnik、Alexei V. Borovikov、Yuriy G. Shermolovich

  DOI：10.1002/hc.20408

  日期：2008.1

  AbstractThe path of the reaction of aryl‐N‐(p‐toluenesulfonyl)‐sulfinimidoyl fluorides and triphenylphosphine is highly dependent on the order of the reactants addition. Addition of triphenylphos‐phine to aryl‐N‐(p‐toluenesulfonyl)‐sulfinimidoyl fluorides results in the formation of triphenyl(aryl‐thio)phosphonium salts of N,N′‐bis(p‐toluenesul‐fonyl)aryl‐sulfinamidines and triphenyldifluorophosphorane. By changing the reagent addition order, we obtained triphenyldifluorophosphorane, P,P,P‐triphenyl‐N‐(p‐toluenesulfonyl)‐phosphine imide, and diaryl disulfides. The outcome of the reaction aryl‐N‐(arenesulfonyl)‐sulfinimidoyl chlorides and triphenylphosphine does not depend on the order of addition of the reactants. P,P,P‐Triphenyl‐N‐(arenesulfonyl)‐phosphine imides, triphenyldichloro‐phosphorane, and diaryl disulfides were formed as a result. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:66–71, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20408
• CLVI.—The preparation of compounds analogous in structure to sulphinic acids but containing p-toluenesulphonimido-groups in place of oxygen atoms. Phenyl- and methyl-p-toluenesulphonimido-sulphine-p-toluenesulphonylimines
  作者：Sydney George Clarke、Joseph Kenyon、Henry Phillips

  DOI：10.1039/jr9300001225

  日期：——
• Leandri; Spinelli, Annali di Chimica, 1959, vol. 49, p. 964,967
  作者：Leandri、Spinelli

  DOI：——

  日期：——
• Barton,D.H.R. et al., Journal of the Chemical Society. Perkin transactions I, 1978, p. 1090 - 1100
  作者：Barton,D.H.R. et al.

  DOI：——

  日期：——