2-(6-methylpyridin-2-yl)-1-[2-(4-((dimethylamino)methyl)-phenyl)-pyridin-4-yl]-ethanone | 656257-83-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(6-methylpyridin-2-yl)-1-[2-(4-((dimethylamino)methyl)-phenyl)-pyridin-4-yl]-ethanone
• 英文别名: 2-(6-Methylpyridin-2-yl)-1-[2-(4-((dimethylamino)methyl)phenyl)-pyridin-4-yl]-ethanone；1-[2-[4-[(dimethylamino)methyl]phenyl]pyridin-4-yl]-2-(6-methylpyridin-2-yl)ethanone
• CAS: 656257-83-9
• 化学式: C₂₂H₂₃N₃O
• 分子量: 345.444
• InChiKey: JQXLGLYYCVQNSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  46.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-(6-methylpyridin-2-yl)-1-[2-(4-formylphenyl)-pyridin-4-yl]-ethanone 、 二甲胺 、 、 在 silica gel 作用下， 生成 2-(6-methylpyridin-2-yl)-1-[2-(4-((dimethylamino)methyl)-phenyl)-pyridin-4-yl]-ethanone
  参考文献：
  名称：

  Compounds

  摘要：

  本发明涉及一种新型的氨基噻唑衍生物，该衍生物是转化生长因子（“TGF”）-β信号通路的抑制剂，特别是抑制TGF-β类型I或类激活素样激酶（“ALK”）-5受体对smad2或smad3的磷酸化，以及该衍生物的制备方法和在医学上的应用，具体地用于治疗和预防由该通路介导的疾病状态。

  公开号：

  US20060004051A1

文献信息

• 2-Phenylpyridin-4-yl derivatives as alk5 inhibitors
  申请人：Dodic Nerina

  公开号：US20050245520A1

  公开（公告）日：2005-11-03

  This invention relates to novel 2-phenylpyridin-4-yl heterocyclyl derivatives which are inhibitors of the transforming growth factor, (“TGF”)-β signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase (“ALK”)-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.

  本发明涉及新型的2-苯基吡啶-4-基杂环基衍生物，其是转化生长因子（“TGF”）-β信号通路的抑制剂，特别是通过TGF-β type I或激活素样激酶（“ALK”）-5受体对smad2或smad3的磷酸化，本发明还涉及其制备方法以及在医学上的使用，具体用于治疗和预防由该通路介导的疾病状态。
• Ethylene/alpha-olefin copolymer made with a non-single-site/single-site catalyst combination, its preparation and use
  申请人：Nowlin Edward Thomas

  公开号：US20050054791A1

  公开（公告）日：2005-03-10

  An ethylene/α-olefin copolymer comprising a component produced by a non-single-site polymerization catalyst and a component produced by a single-site polymerization catalyst, its preparation and use are described. The copolymer has an α-olefin content of 5 to 20 percent by weight aud shows at least two CRYSTAF peak temperatures differing by at least 15° C. and/or at least two DSC melting peak temperatures differing by at least 15° C.

  本文描述了一种乙烯/α-烯烃共聚物，它包括由非单位点聚合催化剂生产的一种组分和由单位点聚合催化剂生产的一种组分及其制备和使用方法。该共聚物的 α-烯烃含量为 5%至 20%（按重量计），至少有两个 CRYSTAF 峰值温度相差至少 15 摄氏度，和/或至少有两个 DSC 熔化峰值温度相差至少 15 摄氏度。
• ETHYLENE/ALPHA-OLEFIN COPOLYMER MADE WITH A NON-SINGLE-SITE/SINGLE-SITE CATALYST COMBINATION, ITS PREPARATION AND USE
  申请人：ExxonMobil Chemical Patents Inc.

  公开号：EP1461364A1

  公开（公告）日：2004-09-29
• [EN] ETHYLENE/ALPHA-OLEFIN COPOLYMER MADE WITH A NON-SINGLE-SITE/SINGLE-SITE CATALYST COMBINATION, ITS PREPARATION AND USE<br/>[FR] COPOLYMERE D'ETHYLENE/D'ALPHA-OLEFINE CONSTITUE D'UNE COMBINAISON DE CATALYSEURS A SITE UNIQUE ET A SITE NON UNIQUE, SA PREPARATION ET SON UTILISATION
  申请人：EXXONMOBIL CHEM PATENTS INC

  公开号：WO2003048213A1

  公开（公告）日：2003-06-12

  An ethylene/α-olefin copolymer comprising a component produced by a non-single-site polymerization catalyst and a component produced by a single-site polymerization catalyst, its preparation and use are described. The copolymer has an α-olefin content of 5 to 20 percent by weight and shows at least two CRYSTAF peak temperatures differing by at least 15 °C and/or at least two DSC melting peak temperatures differing by at least 15 °C.