[N,N'-bis(2-pyridyl-phenyl)methylene-1,4-butanediamine]-(N,N',N'',N''')-copper(II) diperchlorate | 165897-69-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [N,N'-bis(2-pyridyl-phenyl)methylene-1,4-butanediamine]-(N,N',N'',N''')-copper(II) diperchlorate
• CAS: 165897-69-8
• 化学式: C₂₈H₂₆ClCuN₄O₄*ClO₄
• 分子量: 680.988
• InChiKey: USXSDMGRFCHSBE-RDHYOIAFSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  2-苯甲酰吡啶 、 copper(II) perchlorate 、 四亚甲基二胺 以 乙醇 为溶剂， 以39.6%的产率得到[N,N'-bis(2-pyridyl-phenyl)methylene-1,4-butanediamine]-(N,N',N'',N''')-copper(II) diperchlorate
  参考文献：
  名称：

  Phenyl-substituted copper di-Schiff base, a potent Cu2Zn2 superoxide dismutase mimic surviving competitive biochelation

  摘要：

  [N,N'-bis(2-pyridyl-phenyl)methylene-1,4-butanediamine]-(N,N',N '',N''')-copper(II), Cu(II)PuPhePy, a copper(II) di-Schiffbase in both its chloride and perchlorate form, has been prepared and crystallized with a yield of 50+/-10%. IR spectra confirmed the successful preparation. The electronic absorption epsilon(690) was 136 M(-1) cm(-1). The EPR parameters g(perpendicular to)=2.048 and g(parallel to)=2.217 were in dose agreement with the respective values of intact Cu2Zn2 SOD. Comparison of the crystal structures of this complex and the copper binding centre of Cu2Zn2 SOD revealed a virtually identical coordination chemistry. The pulse-radiolytically-determined superoxide dismutation proceeded even in the presence of a fourfold molar excess of EDTA at a rate of 0.48x10(9) M(-1) s(-1). In the indirect nitroblue tetrazolium assay 0.27 mu M of Cu(II)PuPhePy(ClO4)(2) were required to cause 50% inhibition. The thermodynamic stability constant logK=18.33+/-0.77 was calculated from CD data. The stability being two orders of magnitude higher than that of serum albumin, a competitive biological Cu(II) chelator and its 'model' EDTA was deduced. Of all the many superoxide dismutase mimics examined, the present Cu complex is in closest agreement in both structure and catalytic function with the active centre of intact Cu2Zn2 SOD.

  DOI：

  10.1016/0020-1693(94)04298-a