1-tosyl-1,4-cyclohexadiene | 950669-06-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-tosyl-1,4-cyclohexadiene
• 英文别名: 1-(Cyclohexa-1,4-dien-1-ylsulfonyl)-4-methylbenzene；1-cyclohexa-1,4-dien-1-ylsulfonyl-4-methylbenzene
• CAS: 950669-06-4
• 化学式: C₁₃H₁₄O₂S
• 分子量: 234.319
• InChiKey: DOJJDMPMMVYUIN-UHFFFAOYSA-N

物化性质

• 熔点：
  68-69 °C(Solv: ligroine (8032-32-4))
• 沸点：
  411.4±45.0 °C(Predicted)
• 密度：
  1.204±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-tosyl-1,4-cyclohexadiene 在 吡啶 、 4-二甲氨基吡啶 、 potassium osmate(VI) dihydrate 、 甲基磺酰胺 、 potassium carbonate 、 potassium hexacyanoferrate(III) 作用下， 以 二氯甲烷 、 水 、 叔丁醇 为溶剂， 反应 18.0h， 生成 4-tosylcyclohex-4-ene-1,2-diyl bis(2,2-dimethylpropanoate)
  参考文献：
  名称：

  明亮，“可点击”的卟啉，用于在环境光下可视化氧合

  摘要：

  已经开发了一组新的“可点击的”和发光明亮的金属卟啉，以肉眼可视化环境光下的氧合。这些炔基封端的化合物可通过叠氮化物-炔烃点击化学快速而简便地合成氧敏感树状聚合物。由于吸收最大值与常见的商用激光源的波长重叠，因此它们很容易应用于组织氧合的生物医学成像。描述了一种有效的合成方法，该方法具有稳定的三甲基乙酰基（新戊酰基）保护基，可用于制备。包含新的，点击合成的卟啉树枝状大分子的涂有液体的绷带已用于绘制离体猪皮肤烧伤模型的氧合图。

  DOI：

  10.1002/anie.201506847
• 作为产物：
  描述：

  对甲苯基[2-(三甲基甲硅烷基)乙炔基]砜 在 水 、 sodium fluoride 作用下， 以 甲醇 为溶剂， 反应 48.5h， 生成 1-tosyl-1,4-cyclohexadiene
  参考文献：
  名称：

  一种由 4,7-二氢异吲哚合成四苯并卟啉的简便可靠方法

  摘要：

  开发了一种从不稳定异吲哚的最接近的可能前体获得四苯并卟啉的新途径。该路线的一个关键特征是极大地促进了退火环的芳构化，这是以前四苯并卟啉合成中最严重的瓶颈。新方法的能力通过内消旋四芳基四苯并卟啉的合成以及 5,15-二苯基四苯并卟啉的首次明确合成和表征得到说明。 (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007 )

  DOI：

  10.1002/ejoc.200700014

文献信息

• COMPOUNDS, SYSTEMS, AND METHODS FOR MONITORING AND TREATING A SURFACE OF A SUBJECT
  申请人：Evans Conor L.

  公开号：US20160159842A1

  公开（公告）日：2016-06-09

  Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration.

  本文提供了一种设计和组装非侵入式分析物感应敷料的化合物、系统和方法。该敷料可以具有治疗作用。该敷料包括一个传感器和一个基质。传感器能够检测分子氧、二氧化碳、一氧化氮、血浆中溶解的分析物和氢离子等分析物。基质至少部分对分析物具有渗透性。当传感器在分析物存在的情况下被激发时，该装置会发出可检测的信号。在敷料的一个版本中，传感器包括一种对氧敏感的介质未取代的金属卟啉。当在第一波长照射后激发介质未取代的金属卟啉时，会发出磷光，其强度可用作氧浓度的指示器的第二波长的发射。
• Compounds, systems, and methods for monitoring and treating a surface of a subject
  申请人：THE GENERAL HOSPITAL CORPORATION

  公开号：US10039842B2

  公开（公告）日：2018-08-07

  Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration. The porphyrin can have the Formula (II): wherein R1 includes a moiety selected from the group consisting of alkynl groups, triazolyl groups, alkylglutamate groups, and a pair of alkylglutamate groups.

  为设计和组装非侵入式分析物传感敷料提供了化合物、系统和方法。敷料包括传感器和基质。传感器能够检测分析物，如分子氧、二氧化碳、一氧化氮、等离子体中溶解的分析物和氢离子。当传感器在被分析物存在的情况下被激发时，该装置会发出可检测的信号。在一种敷料中，传感器包括对氧敏感的中未取代金属化卟啉。金属化卟啉在第一波长照射时会被激发，然后在第二波长发射磷光，其强度可用作氧气浓度的指示剂。卟啉的化学式为 (II)： 其中 R1 包括选自由炔基、三唑基、烷基谷氨酸基和一对烷基谷氨酸基组成的组的分子。
• 4,8-Dihydropyrrol[3,4-f]isoindole as a Useful Building Block for Near-Infrared Dyes
  作者：Hidemitsu Uno、Mitsunori Nakamura、Kazuki Jodai、Shigeki Mori、Tetsuo Okujima

  DOI：10.3987/com-14-s(k)91

  日期：——

  4,8-Dihydropyrrol[3,4-f]isoindole was prepared from 4,7-dihydroisoindole based on the modified Barton-Zard reaction. Addition of phenylsulfenyl chloride followed by oxidation and dehydrochlorination gave phenylsulfonyldihydroisoindole, which underwent the smooth reaction with an isocyanoacetate under basic conditions to give 4,8-dihydropyrrol[3,4-f]isoindole-1,5- and 1,7-dicarboxylates in good yields. The pyrrolisoindole was successfully converted to the benzene-fused bisBODIPY, absorption maximum of which was 758 nm.
• US9789206B2
  申请人：——

  公开号：US9789206B2

  公开（公告）日：2017-10-17
• [EN] COMPOUNDS, SYSTEMS, AND METHODS FOR MONITORING AND TREATING A SURFACE OF A SUBJECT<br/>[FR] COMPOSÉS, SYSTÈMES ET PROCÉDÉS POUR SURVEILLER ET TRAITER LA SURFACE D'UN SUJET
  申请人：GEN HOSPITAL CORP

  公开号：WO2015006015A1

  公开（公告）日：2015-01-15

  Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration.