(R)-N-(2-hydroxy-1-phenylethyl)-5-methyl-3-(2,4,5-trifluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide | 1231909-14-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-N-(2-hydroxy-1-phenylethyl)-5-methyl-3-(2,4,5-trifluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide
• 英文别名: N-[(1R)-2-hydroxy-1-phenylethyl]-5-methyl-3-(2,4,5-trifluorophenyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-1-carboxamide
• CAS: 1231909-14-0
• 化学式: C₂₂H₂₁F₃N₄O₂
• 分子量: 430.43
• InChiKey: HWUMZKIRKOYGHG-IBGZPJMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  70.4
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  (S)-N-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl)-5-methyl-3-(2,4,5-trifluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide 、 D-苯甘氨醇 生成 (R)-N-(2-hydroxy-1-phenylethyl)-5-methyl-3-(2,4,5-trifluorophenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide
  参考文献：
  名称：

  BICYCLIC PYRAZOLO-HETEROCYCLES

  摘要：

  本发明提供了具有一般式I结构的取代的吡唑杂环化合物，其中环A和B以及取代基Ra、Rb和Rc的结构在说明书中描述。还提供了公认的药用盐、酸盐、水合物、溶剂物和化合物I的立体异构体。这些化合物可用作大麻素受体的调节剂，并用于预防、治疗和抑制与大麻素受体相关的疾病和症状，如疼痛、炎症和瘙痒。

  公开号：

  US20110275609A1

文献信息

• Bicyclic pyrazolo-heterocycles
  申请人：Luo Robert Zhiyong

  公开号：US08653127B2

  公开（公告）日：2014-02-18

  The present invention provides substituted pyrazolo-heterocycles having the general structure of formula I The structures of rings A and B and substituents Ra, Rb and Rc are described in the specification. Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis, treatment and inhibition of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.

  本发明提供了具有公式I的替代嘧唑杂环的化合物，其中环A和B以及取代基Ra、Rb和Rc的结构在说明书中描述。还提供了公式I化合物的药学上可接受的盐、酸盐、水合物、溶剂物和立体异构体。这些化合物可用作大麻素受体的调节剂，并用于预防、治疗和抑制与大麻素受体相关的疾病和病症，如疼痛、炎症和瘙痒症。
• US7741350B1
  申请人：——

  公开号：US7741350B1

  公开（公告）日：2010-06-22
• US8211926B2
  申请人：——

  公开号：US8211926B2

  公开（公告）日：2012-07-03
• US8653127B2
  申请人：——

  公开号：US8653127B2

  公开（公告）日：2014-02-18
• [EN] BICYCLIC PYRAZOLO-HETEROCYCLES<br/>[FR] HÉTÉROCYCLES PYRAZOLO BICYCLIQUES
  申请人：CARA THERAPEUTICS INC

  公开号：WO2010088050A2

  公开（公告）日：2010-08-05

  The present invention provides substituted pyrazolo-heterocycles having the general structure of formula I (I). The structures of rings A and B and substituents Ra, Rb and Rc are described in the specification. Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis, treatment and inhibition of cannabinoid receptor- associated diseases and conditions, such as pain, inflammation and pruritis.