3-[1-(4-chlorophenyl)cyclopropyl]-4,5-dicyclopropyl-4H-1,2,4-triazole | 633317-31-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[1-(4-chlorophenyl)cyclopropyl]-4,5-dicyclopropyl-4H-1,2,4-triazole
• 英文别名: 3-[1-(4-Chlorophenyl)cyclopropyl]-4,5-dicyclopropyl-1,2,4-triazole
• CAS: 633317-31-4
• 化学式: C₁₇H₁₈ClN₃
• 分子量: 299.803
• InChiKey: LQEUYRPXPADGIZ-UHFFFAOYSA-N

物化性质

• 沸点：
  489.2±55.0 °C(Predicted)
• 密度：
  1.50±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP1532122B1

  公开（公告）日：2011-12-14
• Combination therapy for the treatment of diabetes
  申请人：Erondu E. Ngozi

  公开号：US20070099884A1

  公开（公告）日：2007-05-03

  The present invention relates to compositions comprising an anti-obesity agent and an anti-diabetic agent useful for the treatment of diabetes, diabetes associated with obesity and diabetes-related disorders. The present invention further relates to methods of treating or preventing obesity, and obesity-related disorders, in a subject in need thereof by administering a composition of the present invention. The present invention further provides for pharmaceutical compositions, medicaments, and kits useful in carrying out these methods.
• 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11BETA-HSD1) INHIBITORS AND USES THEREOF
  申请人：Jacobson Peer B.

  公开号：US20110159005A1

  公开（公告）日：2011-06-30

  A method for treating a patient suffering from inflammation, chronic inflammation, pain, rheumatoid arthritis (RA), osteoarthritis and osteoporosis, comprising administering an effective amount of a selective inhibitor of the 11-β-hydroxysteroid dehydrogenase Type 1 enzyme.
• US6730690B2
  申请人：——

  公开号：US6730690B2

  公开（公告）日：2004-05-04
• US7179802B2
  申请人：——

  公开号：US7179802B2

  公开（公告）日：2007-02-20