(Z)-N-(benzo[d][1,3]dioxol-5-yl)-2,4-dihydroxy-5-isopropyl-N'-(methylsulfonyl)benzohydrazonamide | 1202513-05-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: (Z)-N-(benzo[d][1,3]dioxol-5-yl)-2,4-dihydroxy-5-isopropyl-N'-(methylsulfonyl)benzohydrazonamide
• 英文别名: N'-(1,3-benzodioxol-5-yl)-2,4-dihydroxy-N-(methanesulfonamido)-5-propan-2-ylbenzenecarboximidamide
• CAS: 1202513-05-0
• 化学式: C₁₈H₂₁N₃O₆S
• 分子量: 407.447
• InChiKey: GQPLOADLMBXHOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  138
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• Hydrazonamide Compounds That Modulate Hsp90 Activity
  申请人：Burlison Joseph A.

  公开号：US20120046288A1

  公开（公告）日：2012-02-23

  The present invention relates to substituted hydrazonamide compounds. The invention further relates to methods of inhibiting the activity of Hsρ90 in a subject in need thereof and methods for treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted hydrazonamide compound of the invention, or a pharmaceutical composition comprising such a compound.
• US8648071B2
  申请人：——

  公开号：US8648071B2

  公开（公告）日：2014-02-11
• [EN] HYDRAZONAMIDE COMPOUNDS THAT MODULATE HSP90 ACTIVITY<br/>[FR] COMPOSÉS D'HYDRAZONAMIDE MODULANT L'ACTIVITÉ DES HSP90
  申请人：SYNTA PHARMACEUTICALS CORP

  公开号：WO2009158026A1

  公开（公告）日：2009-12-30

  The present invention relates to substituted hydrazonamide compounds. The invention further relates to methods of inhibiting the activity of Hsρ90 in a subject in need thereof and methods for treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted hydrazonamide compound of the invention, or a pharmaceutical composition comprising such a compound.