Tert-butyl 2-(8-ethynyl-1,2-dimethyl-7-oxopyrano[3,2-e]indol-3-yl)acetate | 1383942-00-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: Tert-butyl 2-(8-ethynyl-1,2-dimethyl-7-oxopyrano[3,2-e]indol-3-yl)acetate
• CAS: 1383942-00-4
• 化学式: C₂₁H₂₁NO₄
• 分子量: 351.402
• InChiKey: VTFOYTOZOWAVHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  57.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  溴乙酸叔丁酯 、 1,2-dimethyl-8-(2-trimethylsilylethynyl)-3H-pyrano[3,2-e]indol-7-one 在 sodium hydride 、 水 作用下， 以 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 以55%的产率得到Tert-butyl 2-(8-ethynyl-1,2-dimethyl-7-oxopyrano[3,2-e]indol-3-yl)acetate
  参考文献：
  名称：

  A simple selective protocol for continuous two-stage fluorescent sensing of both MeHg+ and anti-MeHg+ agents in living cells

  摘要：

  Methylmercury (MeHg+) is one of the most toxic mercury species targeting human nervous systems, and deficiency of a convenient and precise appraisal model for anti-MeHg+ treatment greatly slows down the step of developing clinically useful anti-MeHg+ agents. A simple visualization model has been demonstrated in this work for selective sensing of both MeHg+ and anti-MeHg+ agents in two continuous stages of one experiment in living cells, using a newly developed fluorescent pyrrolcoumarin probe. The developed sensing protocol shows great potential in the future applications of screening and evaluation of anti-MeHg+ agents. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.04.113