2-氰基丁烷-2-基4-氯-3,5-二甲基-1H-吡唑-1-二硫代酸酯 | 2052159-02-9

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 芳基卤化物
• 中文名称: 2-氰基丁烷-2-基4-氯-3,5-二甲基-1H-吡唑-1-二硫代酸酯
• 英文名称: 2-Cyanobutan-2-yl 4-chloro-3,5-dimethyl-1H-pyrazole-1-carbodithioate
• 英文别名: 2-cyanobutan-2-yl 4-chloro-3,5-dimethylpyrazole-1-carbodithioate
• CAS: 2052159-02-9
• 化学式: C₁₁H₁₄ClN₃S₂
• 分子量: 287.8
• InChiKey: ZQXRXQYJDCRRGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  99
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Polymeric prodrugs and subcutaneous and/or intramuscular administration thereof
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

  公开号：US20200353090A1

  公开（公告）日：2020-11-12

  The invention relates to new prodrugs of active molecules. These prodrugs allow, in particular, the subcutaneous or intramuscular administration of active molecules of which the subcutaneous or intramuscular administration is problematic or impossible, in particular because of the toxicity at the injection site. The prodrugs according to the invention comprise an active ingredient, covalently linked with a polymer chain, preferably a hydrophilic and/or thermosensitive polymer chain. The invention relates, in particular, to polymeric prodrugs comprising a polymer chain formed at least in part by acrylamide monomer or one of its derivatives, the polymer comprising a proximal part and a terminal part; a first pharmaceutically active molecule covalently coupled to the proximal part of the polymer; possibly a second pharmaceutically active molecule covalently coupled to the terminal part of the polymer.

  该发明涉及新型活性分子的前药。这些前药允许特别是将活性分子皮下或肌肉内注射，而这些活性分子的皮下或肌肉内注射由于在注射部位的毒性而具有问题或不可能，特别是由于在注射部位的毒性。根据本发明的前药包括一种活性成分，与一根聚合物链共价连接，优选为一种亲水性和/或热敏感性聚合物链。该发明特别涉及包括由丙烯酰胺单体或其衍生物之一至少部分形成的聚合物链的聚合物前药，该聚合物包括一个近端部分和一个末端部分；第一种药用活性分子共价结合到聚合物的近端部分；可能第二种药用活性分子共价结合到聚合物的末端部分。
• Polymerizable sulfonamide compounds and polymers thereof
  申请人：Massachusetts Institute of Technology

  公开号：US11155674B2

  公开（公告）日：2021-10-26

  Methods, compositions, reagents, and systems that allow for the preparation and utilization of sulfonamide salt polymer electrolytes are disclosed herein. Methods and reagents to prepare sulfonamide salt monomers are also disclosed herein. The sulfonamide salt polymer electrolytes can be used as components in energy storage devices, conductive materials, electrochemical cells, gels, adhesives, and drug delivery vehicles.

  本文公开了允许制备和利用磺胺盐聚合物电解质的方法、组合物、试剂和系统。本文还公开了制备磺胺盐单体的方法和试剂。磺胺盐聚合物电解质可用作能量存储设备、导电材料、电化学电池、凝胶、粘合剂和药物输送载体中的组件。
• BLOCK COPOLYMER AND METHOD FOR PRODUCING BLOCK COPOLYMER
  申请人：Denka Company Limited

  公开号：EP3604367A1

  公开（公告）日：2020-02-05

  To provide a block copolymer that comprises an aromatic vinyl compound polymer and a chloroprene polymer, has a number average molecular weight of 100,000 or more, is preferred for a rubber composition and an adhesive composition, and is suitable for industrial production. A block copolymer comprises at least one aromatic vinyl compound polymer block and at least one chloroprene polymer block, has a functional group with a structure represented by Chemical Formula (1) or (2), and has a number average molecular weight of 100,000 or more. The chloroprene polymer block has a number average molecular weight of 80,000 or more in total. (In Chemical Formula (1), R1 is hydrogen, chlorine, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted heterocyclyl group)

  提供一种嵌段共聚物，它由芳香族乙烯基化合物聚合物和氯丁二烯聚合物组成，具有 100,000 或以上的平均分子量，优选用于橡胶组合物和粘合剂组合物，并适合工业生产。嵌段共聚物由至少一种芳香族乙烯基化合物聚合物嵌段和至少一种氯丁二烯聚合物嵌段组成，具有化学式（1）或（2）所代表结构的官能团，平均分子量大于等于 100,000。氯丁二烯聚合物嵌段的总平均分子量为 80,000 或以上。 (在化学式（1）中，R1 是氢、氯、取代或未取代的烷基、取代或未取代的烯基、取代或未取代的芳基或取代或未取代的杂环基）。
• CHLOROPRENE POLYMER AND PRODUCTION METHOD THEREFOR
  申请人：Denka Company Limited

  公开号：EP3656795A1

  公开（公告）日：2020-05-27

  Provided is a chloroprene-based polymer having an industrially applicable sufficient molecular weight and capable of obtaining a vulcanized rubber excellent in durability and fatigue endurance and an adhesive excellent in layer separation resistance. A chloroprene-based polymer having a number average molecular weight Mn of 150000 to 300000 and comprising a functional group of a structure represented by the general formula (1) or (2) below: (wherein in the general formula (1), R1 shows hydrogen, chlorine, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted heterocyclyl group.)

  本发明提供了一种氯丁二烯基聚合物，该聚合物具有适用于工业的足够分子量，能够获得耐久性和耐疲劳性优异的硫化橡胶以及耐层间分离性优异的粘合剂。一种氯丁二烯基聚合物，其数均分子量 Mn 为 150000 至 300000，并包含由以下通式 (1) 或 (2) 所代表的结构的官能团： (其中在通式(1)中，R1 表示氢、氯、取代或未取代的烷基、取代或未取代的烯基、取代或未取代的芳基或取代或未取代的杂环基)。
• POLYMER MANUFACTURING METHOD
  申请人：Denka Company Limited

  公开号：EP3660057A1

  公开（公告）日：2020-06-03

  The present invention provides a polymer having a narrow molecular weight distribution by living radical polymerization. A polymer manufacturing method comprising a step of performing living radical polymerization using 0.005 to 0.5 parts by mass of an oxygen radical scavenger per 100 parts by mass of a radical polymerizable monomer.

  本发明通过活自由基聚合提供了一种具有窄分子量分布的聚合物。 一种聚合物制造方法，包括以下步骤：每 100 份可自由基聚合单体使用 0.005 至 0.5 份（质量份）氧自由基清除剂进行活自由基聚合。