1-(1,1-Dimethyl-propoxy)-4-nitro-benzene | 2109-80-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(1,1-Dimethyl-propoxy)-4-nitro-benzene
• 英文别名: 1-(2-Methylbutan-2-yloxy)-4-nitrobenzene
• CAS: 2109-80-0
• 化学式: C₁₁H₁₅NO₃
• 分子量: 209.245
• InChiKey: YVYKQTPYDPPJOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Protein-polymer-drug conjugates
  申请人：Asana Biosciences, LLC

  公开号：US10316080B2

  公开（公告）日：2019-06-11

  A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions are also described.

  本文描述了一种聚合物支架，可用于与基于蛋白质的识别分子（PBRM）共轭，形成 PBRM-聚合物-药物共轭物。该支架包括一个或多个末端马来酰亚胺基团。还公开了由该支架制备的 PBRM-聚合物-药物共轭物。还描述了包含该共轭物的组合物、其制备方法以及用该共轭物或其组合物治疗各种疾病的方法。
• PROTEIN-POLYMER-DRUG CONJUGATES
  申请人：Mersana Therapeutics, Inc.

  公开号：US20180140716A1

  公开（公告）日：2018-05-24

  A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions are also described.
• US9808528B2
  申请人：——

  公开号：US9808528B2

  公开（公告）日：2017-11-07