(4,4',6,6'-tetratrifluoromethylbiphenyl-2,2'-diyl)-bis(diphenylphosphine) | 138942-28-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4,4',6,6'-tetratrifluoromethylbiphenyl-2,2'-diyl)-bis(diphenylphosphine)
• 英文别名: (aS)-4,4',6,6'-Tetrakis(trifluoromethyl)-2,2'-bis(diphenylphosphino)-1,1'-biphenyl；[2-[2-diphenylphosphanyl-4,6-bis(trifluoromethyl)phenyl]-3,5-bis(trifluoromethyl)phenyl]-diphenylphosphane
• CAS: 138942-28-6
• 化学式: C₄₀H₂₄F₁₂P₂
• 分子量: 794.559
• InChiKey: UBZFPWZRCWOSGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.5
• 重原子数：
  54
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  12

文献信息

• PROCESS FOR PRODUCING OPTICALLY ACTIVE AMINE
  申请人：TAKASAGO INTERNATIONAL CORPORATION

  公开号：US20150210657A1

  公开（公告）日：2015-07-30

  A process for producing an optically active amine compound, characterized by asymmetrically hydrogenating a prochiral carbon-nitrogen double bond in the presence of a ruthenium complex represented by general formula (1) or (2) (wherein P represents an optically active diphosphine, X represents an anionic group, and Ar represents an optionally substituted arylene group).

  一种制备光学活性胺化合物的方法，其特征在于在存在由通用式（1）或（2）表示的钌配合物的情况下，对一个丙半胱氨基双键进行不对称氢化（其中P代表光学活性二膦，X代表阴离子基团，Ar代表可选择取代的芳基基团）。
• Process for preparing oprtically active trimethyllactic acid and its ester
  申请人：——

  公开号：US20020035271A1

  公开（公告）日：2002-03-21

  The invention relates to a novel process for preparing optically active trimethyllactic acid and/or its esters by catalytic hydrogenation of trimethylpyruvic acid and/or its esters in the presence of noble metal complex catalysts containing phosphorus ligands.

  这项发明涉及一种新的制备光学活性三甲基乳酸和/或其酯的工艺，通过在含有磷配体的贵金属配合物催化剂存在下对三甲基丙酮酸和/或其酯进行催化氢化来实现。
• Process for producing an optically active ruthenium-phosphine complex and process for producing an optically active alcohol by using the complex
  申请人：——

  公开号：US20010039354A1

  公开（公告）日：2001-11-08

  Provided is a process for preparing an optically active ruthenium-phosphine complex represented by the following formula (1): 1 wherein L represents a bidentate ligand compound of a tertiary phosphine; X represents a halogen atom; and * means chiral center (L* is an optically active substance), which comprises reacting a ruthenium-phosphine complex represented by: Ru m X n L p A q or [RuX(D)(L)]X wherein, X and L have the same meanings as described above (L is a racemic modification); A represents triethylamine (Et 3 N), etc.; and m, n, p and q each stands for an integer and D represents benzene, etc. with ½ equivalent of a specific optically active chiral diamine, thereby inactivating one of the enantiomers; and then with a specific optically active diamine derivative, thereby activating the other enantiomer.

  提供了一种制备光学活性的钌-膦配合物的方法，该配合物由以下公式（1）表示：1其中L代表三价膦的双齿配体化合物；X代表卤素原子；*代表手性中心（L*是光学活性物质），包括将由以下表示的钌-膦配合物反应而成：RumXnLpAq或[RuX（D）（L）]X其中，X和L具有如上所述的相同含义（L是外消旋修饰）；A代表三乙胺（Et3N）等；m、n、p和q各代表一个整数，D代表苯等。首先使用特定的光学活性手性二胺的½当量反应，因此使其中一个对映体失活；然后使用特定的光学活性二胺衍生物，因此激活另一个对映体。
• Preparation of Optically Pure Beta-Amino Acids Having Affinity for the Alpha-Delta Protein
  申请人：Herrinton Paul Matthew

  公开号：US20080194841A1

  公开（公告）日：2008-08-14

  Disclosed are materials and methods for preparing optically active β-amino acids, which bind to the alpha-2-delta subunit of a calcium channel and are useful for treating pain, fibromyalgia, and a variety of psychiatric and sleep disorders. The method includes reacting a chiral allyl amine with a 2-alkynoate in the presence of a Lewis acid and a base to give a chiral tertiary enamine, which after reaction with ammonia, is hydrogenated to give optically active β-amino acids.

  本发明涉及制备光学活性β-氨基酸的材料和方法，该氨基酸与钙通道的α-2-δ亚单位结合，并且用于治疗疼痛、纤维肌痛和各种精神和睡眠障碍。该方法包括在路易斯酸和碱的存在下，将手性丙烯基胺与2-炔酸酯反应，得到手性三级恩酰胺，然后与氨反应后，经过氢化作用得到光学活性β-氨基酸。
• PREPARATION OF BETA-AMINO ACIDS HAVING AFFINITY FOR THE ALPHA-2-DELTA PROTEIN
  申请人：Conway Brian G

  公开号：US20090247743A1

  公开（公告）日：2009-10-01

  Disclosed are materials and methods for preparing optically active β-amino acids of Formula 1, which bind to the alpha-2-delta (α2δ) subunit of a calcium channel.

  本发明涉及制备配方1的光学活性β-氨基酸的材料和方法，该配方1结合到钙通道的α2δ亚单位。