butyl N-[(4-ethenylphenyl)-phenylmethyl]carbamate | 1307233-07-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: butyl N-[(4-ethenylphenyl)-phenylmethyl]carbamate
• CAS: 1307233-07-3
• 化学式: C₂₀H₂₃NO₂
• 分子量: 309.408
• InChiKey: YEQNHNJGHKAHQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-乙烯基苯硼酸 、 (Benzenesulfonyl-phenyl-methyl)-carbamic acid butyl ester 在 bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate 、 sodium dodecyl-sulfate 、 potassium carbonate 作用下， 以 水 、 甲苯 为溶剂， 反应 0.17h， 以67%的产率得到butyl N-[(4-ethenylphenyl)-phenylmethyl]carbamate
  参考文献：
  名称：

  Rhodium-catalyzed arylation of α-amido sulfones with arylboronic acids in a water–toluene biphasic system

  摘要：

  An efficient method for the synthesis of N-protected diaryl-methyl-amines was developed through a rhodium-catalyzed arylation of alpha-amido sulfones with arylboronic acids in a water-toluene biphasic system. The use of a base combined with a surfactant played a key role in this biphasic reaction. A diverse range of alpha-branched amine derivatives bearing different functional groups were obtained within 10 min under the present conditions. (C) 2010 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2010.09.056

文献信息

• Rhodium-catalyzed arylation of α-amido sulfones with arylboronic acids in a water–toluene biphasic system
  作者：Xiao-Yong Dou、Qi Shuai、Liang-Nian He、Chao-Jun Li

  DOI：10.1016/j.ica.2010.09.056

  日期：2011.4

  An efficient method for the synthesis of N-protected diaryl-methyl-amines was developed through a rhodium-catalyzed arylation of alpha-amido sulfones with arylboronic acids in a water-toluene biphasic system. The use of a base combined with a surfactant played a key role in this biphasic reaction. A diverse range of alpha-branched amine derivatives bearing different functional groups were obtained within 10 min under the present conditions. (C) 2010 Elsevier B. V. All rights reserved.