3,7-bis-benzoylamino-dibenzothiophene-5,5-dioxide | 127330-65-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 3,7-bis-benzoylamino-dibenzothiophene-5,5-dioxide
• 英文别名: 3,7-Bis-benzoylamino-dibenzothiophen-5,5-dioxid；N,N'-(5,5-Dioxodibenzothiophene-3,7-diyl) bisbenzenamide；N-(7-benzamido-5,5-dioxodibenzothiophen-3-yl)benzamide
• CAS: 127330-65-8
• 化学式: C₂₆H₁₈N₂O₄S
• 分子量: 454.506
• InChiKey: UFTRTOVPHAAPSO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3,7-二溴-5,5-二氧-二苯并噻吩 在 ammonium hydroxide 、 potassium carbonate 、 甲苯 、 copper(l) chloride 作用下， 生成 3,7-bis-benzoylamino-dibenzothiophene-5,5-dioxide
  参考文献：
  名称：

  Courtot; Chang, Bulletin de la Societe Chimique de France, 1931, vol. <4>, p. 1047,1062

  摘要：

  DOI：

文献信息

• Substituted dibenzothiophenes
  申请人：American Cyanamid Company

  公开号：US04965284A1

  公开（公告）日：1990-10-23

  This disclosure described novel derivatives of dibenzothiophene, dibenzothiophene sulfoxide, dibenzothiophene sulfone, thioxanthene, thioxanthene sulfoxide and thioxanthene sulfone which are active as modulators of the mammalian immune response system.

  这份披露描述了新颖的二苯并噻吩衍生物，二苯并噻吩亚氧化物，二苯并噻吩砜，噻吩并芘，噻吩并芘亚氧化物和噻吩并芘砜，它们作为哺乳动物免疫反应系统的调节剂具有活性。
• Substituted dibenzothiaphenes
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0342433A2

  公开（公告）日：1989-11-23

  This disclosure describes novel derivatives of dibenzothiophene, dibenzothiophene sulfoxide, dibenzothiophene sulfone, thioxanthene, thioxanthene sulfoxide and thioxanthene sulfone which are active as modulators of the mammalian immune response system.

  本公开介绍了二苯并噻吩、二苯并噻吩亚砜、二苯并噻吩砜、硫代噻吩、硫代噻吩亚砜和硫代噻吩砜的新型衍生物，这些衍生物作为哺乳动物免疫应答系统的调节剂具有活性。
• Compositions and methods for promoting tissue regeneration
  申请人：——

  公开号：US20020055530A1

  公开（公告）日：2002-05-09

  The present invention relates to compositions and methods for promoting tissue regeneration, preferably neural tissue regeneration. Compositions of the invention include (i) certain diphenyl sulfides, diphenyl sulfoxides, diphenyl sulfones, and sulfide, sulfoxide and sulfones of dibenzothiophene and thioxanthene, as well as various analogues and derivatives of these compounds; (ii) one or more cells harvested from an animal or organism subsequent to the administration of a composition comprising a compound of (i); or (iii) any combination of (i) and (ii). The invention can be useful in treating decreases in neuronal function, for example from injury or disease.

  本发明涉及促进组织再生，最好是神经组织再生的组合物和方法。本发明的组合物包括：(i) 某些二苯基硫化物、二苯基硫氧化物、二苯基砜、二苯并噻吩和硫氧蒽的硫化物、亚砜和砜，以及这些化合物的各种类似物和衍生物；(ii) 施用包含(i)化合物的组合物后从动物或生物体收获的一种或多种细胞；或(iii) (i)和(ii)的任何组合。本发明可用于治疗神经元功能下降，例如因损伤或疾病引起的神经元功能下降。
• Courtot; Evain, Bulletin de la Societe Chimique de France, 1931, vol. <4> 49, p. 527,528
  作者：Courtot、Evain

  DOI：——

  日期：——
• Compositions and methods for promoting neural regeneration
  申请人：Neuberger J. Timothy

  公开号：US20080070963A1

  公开（公告）日：2008-03-20

  The present invention relates to compositions and methods for promoting tissue regeneration, preferably neural tissue regeneration. Compositions of the invention include (i) certain diphenyl sulfides, diphenyl sulfoxides, diphenyl sulfones, and sulfide, sulfoxide and sulfones of dibenzothiophene and thioxanthene, as well as various analogues and derivatives of these compounds; (ii) one or more cells harvested from an animal or organism subsequent to the administration of a composition comprising a compound of (i); or (iii) any combination of (i) and (ii). The invention can be useful in treating decreases in neuronal function, for example from injury or disease.