(2r)-1-(5-Methylfuran-2-yl)propan-2-ol | 851885-28-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: (2r)-1-(5-Methylfuran-2-yl)propan-2-ol
• CAS: 851885-28-4
• 化学式: C₈H₁₂O₂
• 分子量: 140.182
• InChiKey: VIDXNSNCXZIGNJ-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  33.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] PYRIDINE CARBOXYLIC ACID DERIVATIVES AS GLUCOKINASE MODULATORS<br/>[FR] DERIVES D'ACIDES CARBOXYLIQUE DE PYRIDINE EN TANT QUE MODULATEURS DE LA GLUCOKINASE
  申请人：ASTRAZENECA AB

  公开号：WO2005044801A1

  公开（公告）日：2005-05-19

  A compound of Formula (I): wherein: A is phenyl or a 5- or 6-membered heteroaryl ring, optionally substituted; R1 and R2 are selected from hydrogen and methyl; with the proviso that at least one of R1 and R2 is methyl; or a salt, pro-drug or solvate thereof, are described. Their use as GLK activators, pharmaceutical compositions containing them, and processes for their preparation are also described.

  式(I)的化合物：其中：A为苯基或5-或6-成员杂环芳基环，可选择地取代；R1和R2从氢和甲基中选取；条件是R1和R2中至少有一个为甲基；或其盐、前药或溶剂化合物。描述了它们作为GLK激活剂的用途，含有它们的药物组合物以及它们的制备方法。
• PYRIDINE CARBOXYLIC ACID DERIVATIVES AS GLUCOKINASE MODULATORS
  申请人：Caulkett William Rodney Peter

  公开号：US20070078168A1

  公开（公告）日：2007-04-05

  A compound of Formula (I): wherein: A is phenyl or a 5- or 6-membered heteroaryl ring, optionally substituted; R 1 and R 2 are selected from hydrogen and methyl; with the proviso that at least one of R 1 and R 2 is methyl; or a salt, pro-drug or solvate thereof, are described. Their use as GLK activators, pharmaceutical compositions containing them, and processes for their preparation are also described.

  公式（I）的化合物：其中：A为苯基或5或6成员的杂环芳基环，可选择取代；R1和R2为氢或甲基；但至少有一个R1和R2为甲基；或其盐、前药或溶剂化物。描述了它们作为GLK激活剂的用途，包含它们的制药组合物以及它们的制备方法。