6-(2-Chloro-4-methylanilino)-4-[4-cyclopropyl-5-[3-(2-methylpropyl)cyclobutyl]-1,2-oxazol-3-yl]-6-oxohexanoic acid | 1404378-01-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-(2-Chloro-4-methylanilino)-4-[4-cyclopropyl-5-[3-(2-methylpropyl)cyclobutyl]-1,2-oxazol-3-yl]-6-oxohexanoic acid
• CAS: 1404378-01-3
• 化学式: C₂₇H₃₅ClN₂O₄
• 分子量: 487.039
• InChiKey: DCYKRJXXWKNGIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  34
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  92.4
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• AMIDE COMPOUND AND MEDICINAL USE THEREOF
  申请人：Maeba Takaki

  公开号：US20120322837A1

  公开（公告）日：2012-12-20

  A compound of formula [I-W]: wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.

  翻译结果为：具有公式[I-W]的化合物：其中每个符号如描述中定义，或其药物可接受的盐。
• Amide compound and pharmaceutical application therefor
  申请人：Japan Tobacco Inc.

  公开号：EP2927217A1

  公开（公告）日：2015-10-07

  A compound of formula [I-W]: wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.

  式 [I-W] 的化合物： 其中各符号如描述中所定义，或其药学上可接受的盐。
• AMIDE COMPOUND AND PHARMACEUTICAL APPLICATION THEREFOR
  申请人：Japan Tobacco Inc.

  公开号：EP2927217B1

  公开（公告）日：2018-01-17
• TREATMENT FOR RETINOIC ACID RECEPTOR-RELATED ORPHAN RECEPTOR Ɣ (RORƔ)-DEPENDENT CANCERS
  申请人：The Regents of the University of California

  公开号：US20220202811A1

  公开（公告）日：2022-06-30

  Described are compositions and methods for the treatment of an RORγ-dependent cancer, including pancreatic cancer, lung cancer, leukemia, etc. In some example implementations, pharmaceutical compositions for cancer treatment comprising RORγ inhibitors and optionally other therapeutic agents, as well as methods of treating cancer using the pharmaceutical compositions are disclosed.