N¹-<6-Dimethylamino-pyrimidyl-(4)>-sulfanilamid | 1224-82-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N¹-<6-Dimethylamino-pyrimidyl-(4)>-sulfanilamid
• 英文别名: 4-amino-N-(6-dimethylamino-pyrimidin-4-yl)-benzenesulfonamide；4-amino-N-[6-(dimethylamino)pyrimidin-4-yl]benzenesulfonamide
• CAS: 1224-82-4
• 化学式: C₁₂H₁₅N₅O₂S
• 分子量: 293.349
• InChiKey: OWDDLGDOIJFXQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Compositions and methods for treating cognitive disorders
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2301625A2

  公开（公告）日：2011-03-30

  Use of selective antagonists of the 5-HT6 receptor and 5-HT2A receptors for the preparation of medicaments and corresponding pharmaceutical compositions useful for the treatment of cognitive disorders are presented.

  介绍了如何利用 5-HT6 受体和 5-HT2A 受体的选择性拮抗剂来制备治疗认知障碍的药物和相应的药物组合物。
• Sulfonamide und ihre Verwendung
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0815861B1

  公开（公告）日：2001-09-19
• COMPOSITIONS AND METHODS FOR TREATING COGNITIVE DISORDERS
  申请人：F. Hoffmann-Roche AG

  公开号：EP1799306A2

  公开（公告）日：2007-06-27
• Multimediator Dopamine Transport Inhibitors, and Uses Related Thereto
  申请人：Hauske James R.

  公开号：US20090054489A1

  公开（公告）日：2009-02-26

  The invention provides a class of DAT-5HT2 antagonists, packaged pharmaceuticals comprising such antagonists, and their uses in treating, or manufacturing medicaments for treating disease conditions, including a movement disorder, attention deficit disorder or attention-deficit hyperactivity disorder, anxiety, depression or psychotic disorder. Related business methods such as marketing the inhibitors to healthcare providers are also provided.
• US5932599A
  申请人：——

  公开号：US5932599A

  公开（公告）日：1999-08-03