(3-aminophenyl)[4-(methylsulfanyl)phenyl]methanone | 99642-13-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-aminophenyl)[4-(methylsulfanyl)phenyl]methanone
• 英文别名: (3-Aminophenyl)-(4-methylsulfanylphenyl)methanone
• CAS: 99642-13-4
• 化学式: C₁₄H₁₃NOS
• 分子量: 243.329
• InChiKey: XGCAHUSGWZWXKJ-UHFFFAOYSA-N

物化性质

• 沸点：
  448.4±30.0 °C(Predicted)
• 密度：
  1.23±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  68.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (3-aminophenyl)[4-(methylsulfanyl)phenyl]methanone 在 吡啶 、 盐酸羟胺 作用下， 以 乙醇 为溶剂， 反应 11.0h， 生成 1-(dimethylsulfamoylamino)-3-[(E)-N-hydroxy-C-(4-methylsulfanylphenyl)carbonimidoyl]benzene
  参考文献：
  名称：

  Synthesis and antiviral activity of sulfonamidobenzophenone oximes and sulfonamidobenzamides

  摘要：

  To find antiviral agents, various sulfonamidobenzophenone oximes (II) were synthesized from the appropriate m-sulfonamidobenzophenones by hydroxylamine reaction. The reaction products were generally obtained as syn/anti mixtures which were separable by fractional crystallization. The anti isomer had more potent antipoliovirus activity than the syn isomer. Various sulfonamidobenzamides (III) which were structurally related to II were synthesized by the reactions of amino-substituted benzamides with sulfuryl chloride or amines with (aminosulfonyl)benzoyl chloride. Antiviral activity was examined by the plaque-inhibition test. Compounds 5, 36, and 69 exhibited strong antipicornavirus activity. The structure-activity relationships are discussed.

  DOI：

  10.1021/jm00153a018

文献信息

• Rho-kinase inhibitors
  申请人：BAYER CORPORATION

  公开号：US20040002508A1

  公开（公告）日：2004-01-01

  Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

  本文披露了化合物及其衍生物、它们的合成以及它们作为Rho激酶抑制剂的用途。这些化合物可用于抑制肿瘤生长、治疗勃起功能障碍，以及治疗其他由Rho激酶介导的疾病，例如冠心病。
• Substituted benzoylhaloalkanesulfonanilides
  申请人：RIKER LABORATORIES, INC.

  公开号：US03725451A1

  公开（公告）日：1973-04-03

  Benzoylhaloalkanesulfonanilides having ring substituents selected from amino, nitro, carboxyl, mercapto, phenylsulfinyl, phenylsulfonyl, lower alkylsulfonamido, lower alkanoylamino, lower alkylthio, lower alkanoyloxy, lower alkylsulfamoyl, lower alkylsulfonoxy and lower haloalkylsulfonoxy. These compounds and salts thereof are active anti-inflammatory agents and some also have anti-pyretic and analgesic activity.

  选自氨基、硝基、羧基、巯基、苯基亚磺酰基、苯基磺酰基、低碳烷基磺酰胺基、低碳酰胺基、低碳硫基、低碳酰氧基、低碳烷基磺酰氨基、低碳烷基磺酸酯氧基和低碳卤代烷基磺酸酯氧基的苯甲酰卤代烷烷基磺酰苯胺类化合物及其盐是活性抗炎药物，其中一些还具有抗热和镇痛作用。
• Rho-Kinase Inhibitors
  申请人：Nagarathnam Dhanapalan

  公开号：US20120053179A1

  公开（公告）日：2012-03-01

  Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

  本发明揭示了化合物及其衍生物，它们的合成以及它们作为Rho-kinase抑制剂的用途。这些化合物对于抑制肿瘤生长、治疗勃起功能障碍以及治疗其他由Rho-kinase介导的适应症，例如冠心病，是有用的。
• RHO-KINASE INHIBITORS
  申请人：NAGARAHNAM Dhanapalan

  公开号：US20120302587A1

  公开（公告）日：2012-11-29

  Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

  本发明涉及化合物及其衍生物，其合成以及其作为Rho-激酶抑制剂的用途。这些化合物可用于抑制肿瘤生长，治疗勃起功能障碍以及治疗其他由Rho-激酶介导的适应症，例如冠心病。
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: F: PerFHalOrg.SVol.3, 6.2.3.4, page 152 - 186
  作者：

  DOI：——

  日期：——