Chiral Diacylhydrazine Ligands for Modulating the Expression of Exogenous Genes via an Ecdysone Receptor Complex
申请人:HORMANN Robert Eugene
公开号:US20120116090A1
公开(公告)日:2012-05-10
The present invention provides diacylhydrazine ligands and chiral diacylhydrazine ligands for use with ecdysone receptor-based inducible gene expression systems. Thus, the present invention is useful for applications such as gene therapy, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable. An advantage of the present invention is that it provides a means to regulate gene expression and to tailor expression levels to suit the user's requirements.
本发明提供了用于基于
蜕皮激素受体的诱导
基因表达系统的二酰
肼配体和手性二酰
肼配体。因此,本发明适用于
基因治疗、大规模蛋白质和
抗体生产、基于细胞的筛选分析、功能
基因组学、蛋白质组学、代谢组学和转
基因生物特征调控等应用中,其中需要控制
基因表达
水平。本发明的优点在于提供了一种调节
基因表达并根据用户要求定制表达
水平的手段。