Ethyl 5-(4-methoxyphenyl)-1,3,7-trimethyl-2,4-dioxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylate | 1333490-07-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: Ethyl 5-(4-methoxyphenyl)-1,3,7-trimethyl-2,4-dioxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylate
• 英文别名: ethyl 5-(4-methoxyphenyl)-1,3,7-trimethyl-2,4-dioxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylate
• CAS: 1333490-07-5
• 化学式: C₂₀H₂₃N₃O₅
• 分子量: 385.42
• InChiKey: VRNKIEFNJJOAGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  88.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1,3-二甲基-6-氨基脲嘧啶 、 乙酰乙酸乙酯 、 4-甲氧基苯甲醛 在 Fe₃O₄/SiO₂-SO₃H 作用下， 以 水 为溶剂， 反应 0.58h， 以87%的产率得到Ethyl 5-(4-methoxyphenyl)-1,3,7-trimethyl-2,4-dioxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylate
  参考文献：
  名称：

  Nano-Fe3O4 encapsulated-silica particles bearing sulfonic acid groups as a magnetically separable catalyst for green and efficient synthesis of functionalized pyrimido[4,5-b]quinolines and indeno fused pyrido[2,3-d]pyrimidines in water

  摘要：

  The magnetic nanoparticles supported silica sulfuric acid was used as an efficient catalyst for the synthesis of pyrimido[4,5-b]quinolines and indeno fused pyrido[2,3-d]pyrimidines in water. The desired products were obtained in excellent yields. Fe3O4@SiO2-SO3H was readily recovered using an external magnet and could be reused several times without significant loss of reactivity. (C) 2013 Firouzeh Nemati. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2013.02.018

文献信息

• Thiourea dioxide in water as a recyclable catalyst for the synthesis of structurally diverse dihydropyrido[2,3-d]pyrimidine-2,4-diones
  作者：Sanny Verma、Suman L. Jain

  DOI：10.1016/j.tetlet.2012.03.037

  日期：2012.5

  A series of dihydropyrido[2,3-d]pyrimidine-2,4-diones derivatives were synthesized by the three-component reaction of 6-amino-1,3-dimethyl uracil, aromatic aldehydes, and 1,3-dicarbonyl compound catalyzed by thiourea dioxide in aqueous media. Importantly, the aqueous layer containing thiourea dioxide could be reused for several runs without significant loss in catalytic activity. This method provided several advantages such as inexpensive, recyclable catalyst, easier work-up, milder reaction conditions and environmental benign nature. (C) 2012 Elsevier Ltd. All rights reserved.