4-(3-硝基苯氧基)苯胺 | 60732-27-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(3-硝基苯氧基)苯胺
• 英文名称: 4-(3-nitrophenoxy)phenylamine
• 英文别名: 4-(3-nitro-phenoxy)-aniline；4-(3-Nitro-phenoxy)-anilin；4-(3-Nitrophenoxy)aniline
• CAS: 60732-27-6
• 化学式: C₁₂H₁₀N₂O₃
• 分子量: 230.223
• InChiKey: TVRVOLGSUKJHPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  81.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(3-硝基苯氧基)苯胺 在 碳酸氢钠 作用下， 以 二氯甲烷 、 水 、 甲苯 为溶剂， 反应 24.75h， 生成 1-((1R,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-1-methyl-3-[4-(3-nitro-phenoxy)-phenyl]-urea
  参考文献：
  名称：

  Synthesis and Structure−Activity Relationships of Trisubstituted Phenyl Urea Derivatives as Neuropeptide Y5 Receptor Antagonists

  摘要：

  1-((1R,2R)-2-Hydroxy-1-methyl-2-phenylethyl)-1-methyl-3-(4-phenoxyphenyl)urea (1) was identified as a hit from the screening of the neuropeptide Y5 (NPY5) receptor. This lead was optimized for in vitro potency by changing the stereochemistry, the phenylethyl segment, the urea portion, and the 4-phenoxyphenyl group on the molecule. Over 40 analogues of 1 were prepared to study the structure-activity relationship for this series. The most potent compounds in this class have IC(50)s less than 0.1 nM at the NPY5 receptor (e.g., 40f, 44a, and 47). To determine the functional activity for this series of compounds, selected analogues were tested in acellular assay measuring forskolin-induced cyclic AMP accumulation in 293 cells transfected with the human NPY5 receptor. All urea analogues tested in the functional assay acted as antagonists (e.g., 1, 32, 40a, and 44e).

  DOI：

  10.1021/jm0004547
• 作为产物：
  描述：

  对氨基苯酚 、 1,3-二硝基苯 生成 4-(3-硝基苯氧基)苯胺
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Process and novel intermediate for the preparation of 3,4'-diaminodiphenyl ether
  申请人：Bromine Compounds Ltd.

  公开号：EP0477853A1

  公开（公告）日：1992-04-01

  In a process for the preparation of 3,4'-diaminodiphenyl ether, 3-nitrodiphenyl ether is reacted with a compound selected from Br2 and HN03 to yield a compound of the formula: wherein R is Br or N02; and then carrying out, in any appropriate order, the steps of: (a) substituting any Br atom in the 4'-position with an NH2 group; (b) reducing any N02 group to an NH2 group.

  在制备3,4'-二氨基二苯醚的过程中，将3-硝基二苯醚与Br2和HN03中选择的化合物反应，得到下式化合物：其中R为Br或N02; 然后按任何适当的顺序进行以下步骤：(a)用NH2基替换4'-位的任何Br原子；(b)将任何N02基还原为NH2基。
• EPOXY COMPOUND AND MANUFACTURING METHOD THEREOF
  申请人：Ono Koutaro

  公开号：US20110040111A1

  公开（公告）日：2011-02-17

  A novel epoxy compound represented by the following formula and a method for producing the same are provided: wherein R 1 and R 2 are members selected from the group consisting of hydrogen, aliphatic hydrocarbon group having 1 to 4 carbon atoms, alicyclic hydrocarbon group having 3 to 6 carbon atoms, aromatic hydrocarbon group having 6 to 10 carbon atoms, halogen atom, ether group, ester group, acyl group and nitro group, n is an integer of 1 to 4, and m is an integer of 1 to 5.

  提供了一种由以下式表示的新型环氧化合物及其制备方法：其中R1和R2是从氢、具有1至4个碳原子的脂肪烃基、具有3至6个碳原子的脂环烃基、具有6至10个碳原子的芳香烃基、卤原子、醚基、酯基、酰基和硝基组成的群体中选择的成员，n是1至4的整数，m是1至5的整数。
• PREPREG AND CARBON FIBER-REINFORCED COMPOSITE MATERIAL
  申请人：TORAY INDUSTRIES, INC.

  公开号：US20150210813A1

  公开（公告）日：2015-07-30

  A prepreg includes; sizing agent-coated carbon fibers coated with a sizing agent; and a thermosetting resin composition impregnated into the sizing agent-coated carbon fibers. The sizing agent includes an aliphatic epoxy compound (A) and an aromatic compound (B) at least containing an aromatic epoxy compound (B1). The thermosetting resin composition includes a thermosetting resin (D) and a latent hardener (E), and optionally includes an additive (F) other than the thermosetting resin (D) and the latent hardener (E). The (a)/(b) ratio is within a predetermined range where (a) is the height of a component at a binding energy assigned to CHx, C—C, and C═C and (b) is the height of a component at a binding energy assigned to C—O in a C 1s core spectrum of the surfaces of the sizing agent-coated carbon fibers analyzed by X-ray photoelectron spectroscopy.

  预浸料包括：涂有分散剂的碳纤维，涂有分散剂；以及浸渍在涂有分散剂的碳纤维中的热固性树脂组合物。分散剂包括脂肪族环氧化合物（A）和至少含有芳香族环氧化合物（B1）的芳香族化合物（B）。热固性树脂组合物包括热固性树脂（D）和潜在硬化剂（E），并且可选地包括除热固性树脂（D）和潜在硬化剂（E）以外的添加剂（F）。在由X射线光电子能谱分析的涂有分散剂的碳纤维表面的C1s光谱中，（a）是分配给CHx，C-C和C═C的结合能的组分高度，（b）是分配给C-O的结合能的组分高度，（a）/（b）比值在预定范围内。
• PREPREG AND CARBON FIBER REINFORCED COMPOSITE MATERIAL
  申请人：TORAY INDUSTRIES, INC.

  公开号：US20150252184A1

  公开（公告）日：2015-09-10

  To provide a prepreg and a carbon fiber reinforced composite material that are excellent in adhesion between a matrix resin and carbon fibers and long-term storage stability and also excellent in microcrack resistance due to the increased toughness. The present invention provides a prepreg that includes; agent-coated carbon fibers coated with a sizing agent; and a thermosetting resin composition impregnated into the sizing agent-coated carbon fibers. The sizing agent includes an aliphatic epoxy compound (A) and an aromatic epoxy compound (B1). The sizing agent-coated carbon fibers are in a shape of woven fabric or braid. The thermosetting resin composition includes a thermosetting resin (D), a thermoplastic resin (F), and a latent hardener (G). The sizing agent-coated carbon fibers have an (a)/(b) ratio in a certain range where (a) is the height of a component at a binding energy assigned to CHx, C—C, and C═C and (b) is the height of a component at a binding energy assigned to C—O in a C 1s core spectrum of the surfaces of the sizing agent-coated carbon fibers analyzed by X-ray photoelectron spectroscopy.

  提供一种预浸料和碳纤维增强复合材料，其在基体树脂和碳纤维之间具有优异的附着性和长期储存稳定性，并且由于增加韧性而具有优异的微裂纹抗性。本发明提供一种预浸料，其包括：涂有分散剂的碳纤维；以及浸渍在涂有分散剂的碳纤维中的热固性树脂组合物。分散剂包括脂肪族环氧化合物（A）和芳香族环氧化合物（B1）。涂有分散剂的碳纤维呈编织物或编织带状。热固性树脂组合物包括热固性树脂（D）、热塑性树脂（F）和潜在硬化剂（G）。涂有分散剂的碳纤维在X射线光电子能谱分析的表面C1s谱中，具有（a）在分配给CHx、C—C和C═C的结合能处的组分高度和（b）在分配给C—O的结合能处的组分高度之间的（a）/（b）比率在一定范围内。
• Process for preparing 3,4'-Amino-Nitro-Diphenylether
  申请人：——

  公开号：EP0145377A3

  公开（公告）日：1986-10-29

  A process for preparing 3,4'-amino-nitro-diphenylether in a heterogenous phase, according to the phase-transfer catalysis method, in which para-chloro-nitrobenzene is reacted with an alkali metal or alkaline-earth metal salt, preferably sodium or potassium, of meta-amino-phenol, preferably at a temperature ranging from 50°C to 120°C, in the presence of a phase-transfer catalyst, preferably (1) an onium salt, more preferably a quaternary alkylammonium salt (QR4R wherein 0 is selected from N, P, As, Sb etc., R is an alkyl radical containing up to 20 carbon atoms and Y is Cl, Br, or i, or (2) a crown ether, in a two-phase system consisting of (a) an organic phase represented by the para-chloro-nitrobenzene, optionally in an organic solution, and (b) by the meta-amino-phenol in the form of an alkali metal or alkaline-earth metal salt in an aqueous solution which is substantially immiscible with the first phase.In this way, 3,4'-amino-nitro-diphenylether is obtained, which is a particularly useful intermediate for preparing fibres.

  一种根据相转移催化法在异质相中制备 3,4'-氨基硝基二苯醚的工艺，其中对氯硝基苯与碱金属或碱土金属盐，最好是钠盐或钾盐反应、在相转移催化剂的存在下，最好在 50°C 至 120°C 的温度范围内，使对氯硝基苯与偏氨基苯酚的碱金属或碱土金属盐（最好是钠盐或钾盐）反应，催化剂最好是 (1) 鎓盐，更优选的是季烷基铵盐（QR4R，其中 0 选自 N、P、As、Sb 等）。,R 是含有多达 20 个碳原子的烷基，Y 是 Cl、Br 或 i，或 (2) 冠醚，两相体系包括：(a) 对氯硝基苯代表的有机相，可选有机溶液；(b) 与第一相基本不相溶的水溶液中的碱金属或碱土金属盐形式的偏氨基苯酚。这样就得到了 3,4'-氨基硝基二苯醚，它是制备纤维特别有用的中间体。